机构：[1]Department of Neurology, Chinese PLA General Hospital, Beijing, China[2]Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China[3]Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China[4]Department of Neurology, Peking University the Third Hospital, Beijing, China[5]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China[6]Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China[7]Department of Neurology, Qilu Hospital, Shandong University, Jinan, China[8]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[9]Department of Neurology, Jiangsu Province Hospital, Nanjing, China[10]Department of Neurology, The Second Hospital of Hebei Medical University, Shi jiangzhuang, China
Background - The epidemiology, diagnosis, and treatment of motor neuron disease (MND) in Chinese patients are ill known. Methods - A registered study of 461 MND patients was conducted across 10 facilities in 7 Chinese cities from February 2009 to March 2010. Results - Patients were classified as amyotrophic lateral sclerosis (ALS) (84.4%), progressive bulbar palsy (PBP) (4.1%), progressive muscular atrophy (PMA) (10.4%), or primary lateral sclerosis (PLS) (0.9%). MND was predominant in men (men/women; 1.6: 1.0). Mean onset age was 52.6 years, with the highest incidence being observed between 51 and 60 years. Notably, 26.0% of MND patients were employed in forestry, fishery, or animal husbandry industries. Ten cases (2.7%) reported family history of MND, and 54.2% exhibited cervical onset. MND was also associated with head/neck trauma. Non-invasive positive pressure ventilation was the most common supportive therapy. Conclusion - As a novel comprehensive report of a Chinese population, this study reveals that epidemiological characteristics of MND patients were similar to those observed in international populations. MND is age-related, male gender predominant, and may be associated with both environmental and genetic risk factors.
第一作者机构：[1]Department of Neurology, Chinese PLA General Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, PLA General Hospital, 100853 Beijing, China[*2]Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, China[*3]Department of Neurology, Peking University Third Hospital, 100191 Beijing, China
推荐引用方式(GB/T 7714)：
F. Cui,M. Liu,Y. Chen,et al.Epidemiological characteristics of motor neuron disease in Chinese patients[J].ACTA NEUROLOGICA SCANDINAVICA.2014,130(2):111-117.doi:10.1111/ane.12240.
APA：
F. Cui,M. Liu,Y. Chen,X. Huang,L. Cui...&L. Wang.(2014).Epidemiological characteristics of motor neuron disease in Chinese patients.ACTA NEUROLOGICA SCANDINAVICA,130,(2)
MLA：
F. Cui,et al."Epidemiological characteristics of motor neuron disease in Chinese patients".ACTA NEUROLOGICA SCANDINAVICA 130..2(2014):111-117
