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Alterations in regional homogeneity and functional connectivity in the cerebellum of patients with sporadic amyotrophic lateral sclerosis

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收录情况： ◇ SCIE

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机构： [1]Medical School of Chinese PLA, Beijing, China [2]Department of Neurology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China [3]Department of Neurology, Strategic Support Force Medical Center, Beijing, China [4]Department of Radiology, Southwest Hospital, Third Military Medical University, Army Medical University, Chongqing, China [5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [6]Department of Geriatrics of the Seventh Medical Center, Chinese PLA General Hospital, Beijing, China [7]Department of Radiology, Strategic Support Force Medical Center, Beijing, China

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关键词： Amyotrophic lateral sclerosis Cerebellum Resting state functional magnetic resonance imaging Regional homogeneity Functional connectivity Motor neuron disease

摘要：

The purpose of this study was to examine the cerebellum's local and global functional characteristics in individuals with sporadic amyotrophic lateral sclerosis (sALS) and their correlation with clinical data.Resting-state functional magnetic resonance imaging was performed on 39 patients with sALS and on 23 healthy controls. Regional homogeneity (ReHo) in the cerebellum of all participants was analyzed, and the cerebellar regions with differences in ReHo were considered regions of interest (ROIs). In addition, the functional connectivity between the ROIs and other brain regions was analyzed.In patients with sALS, ReHo increased in parts of the posterior cerebellar lobe. Then, the two regions with increased ReHo of the cerebellum were used as seeds, and further analysis revealed that the connectivity of the right cerebellum to the right medial superior frontal gyrus, left lingual gyrus (calcarine sulcus), left precentral gyrus, left supplementary motor area, and right Crus II was significantly increased.The results demonstrate that resting-state functional connectivity changes in both motor and extra-motor regions of the cerebellum in patients with sALS, and that the cerebellum plays a pathophysiological role in sALS.Copyright © 2023. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 3 区心理学

小类 | 4 区行为科学 4 区神经科学

最新[2023]版：

大类 | 3 区心理学

小类 | 4 区行为科学 4 区神经科学

JCR分区：

出版当年[2022]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

最新[2023]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子： 2.6 最新[2023版] 2.8 最新五年平均 2.7 出版当年[2022版] 3 出版当年五年平均 3.352 出版前一年[2021版] 2.6 出版后一年[2023版]

第一作者：

第一作者机构： [1]Medical School of Chinese PLA, Beijing, China [2]Department of Neurology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China [3]Department of Neurology, Strategic Support Force Medical Center, Beijing, China

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通讯作者：

通讯机构： [1]Medical School of Chinese PLA, Beijing, China [2]Department of Neurology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China [*1]Medical School of Chinese PLA, Beijing, China.

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Alterations in regional homogeneity and functional connectivity in the cerebellum of patients with sporadic amyotrophic lateral sclerosis

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