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Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients

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收录情况： ◇ SCIE

作者：
Yang Song[1] * ; Hui Ding[1] * ; Jingfang Yang[1] * ; Qingling Lin[1] ; Jinhua Xue[1] ; Yanli Zhang[1] ; Piu Chan[1] ; Yanning Cai[1,*1] ;
机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053, PR China
出处：
DOI： 10.1016/j.neulet.2014.03.076
ISSN：

关键词： alpha-Synuclein DNA methylation Pyrosequencing Leukocytes

摘要：
DNA methylation of a CpG island located in intron 1 of the alpha-synuclein gene (SNCA) has been reported to play an essential role in the regulation of alpha-synuclein transcription, and probably has a close association with Parkinson's disease (PD). However, there is no simple and cost effective method to quantify DNA methylation in this region. Additionally, whether this CpG island is hypomethylated in peripheral blood in PD and can be used as PD biomarker is still under debate. In the present study, we developed a set of bisulfite pyrosequencing assays which can be used to examine the DNA methylation level of 13 CpG sites in intron 1 of SNCA. We compared DNA methylation levels at these sites in leukocytes from 50 PD patients and 50 healthy controls. Our results indicated that there were no significant differences in DNA methylation between PD patients and controls. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

基金：
the National Natural ScienceFoundation of China (81071011) the Program for New CenturyExcellent Talents in University (NCET-10-0013) Beijing Healthand Technical Personal of High-Level Plan (Number 008-0023)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
JCR分区：
出版当年[2012]版：
Q3 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者：
第一作者机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053, PR China
共同第一作者：
通讯作者：
通讯机构： [*1]Department of Neurobiology, Xuanwu Hospital of Cap-ital Medical University, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yang Song,Hui Ding,Jingfang Yang,et al.Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients[J].NEUROSCIENCE LETTERS.2014,569:85-88.doi:10.1016/j.neulet.2014.03.076.
APA：
Yang Song,Hui Ding,Jingfang Yang,Qingling Lin,Jinhua Xue...&Yanning Cai.(2014).Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients.NEUROSCIENCE LETTERS,569,
MLA：
Yang Song,et al."Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients".NEUROSCIENCE LETTERS 569.(2014):85-88

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