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Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease

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机构: [1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
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关键词: Alpha-synuclein peripheral tissues Parkinson's disease

摘要:
Parkinson's disease (PD) is a common neurodegenerative disorder. To date, the diagnosis of PD relies mainly on clinical manifestations whereas neuropathological confirmation of the brain is only possible with postmortem studies. Neuronal loss in the substantia nigra pars compacta (SNc) associated with Lewy bodies/neurites is the pathological hallmark feature of PD. The major component of Lewy pathology (LP) is misfolded alpha-synuclein (alpha-SYN). There is evidence that the distribution of LP is not only limited to the brain but extends to peripheral tissues, including gastrointestinal tract, salivary glands, olfactory mucosa, skin, retina, adrenal gland, and heart. Sensitivity and specificity of alpha-SYN detection in PD vary greatly among studies due to methodological heterogeneity, such as sampling sites and size, tissue preparation, staining techniques, and antibodies used. Of note, alpha-SYN has also been found in preclinical and prodromal PD. Further in vivo studies focusing on favorable biopsy sites and standard techniques are needed to get better understanding of alpha-SYN deposits in preclinical, prodromal, and clinical PD.

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出版当年[2018]版:
大类 | 2 区 医学
小类 | 1 区 药物化学 3 区 生化与分子生物学 3 区 神经科学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 药物化学 3 区 神经科学
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出版当年[2017]版:
Q1 NEUROSCIENCES Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, MEDICINAL
最新[2023]版:
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NEUROSCIENCES Q2 CHEMISTRY, MEDICINAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者:
第一作者机构: [1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
通讯作者:
通讯机构: [1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China [*1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #119 South fourth Ring Road, West Road, 100070, Beijing, China.
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