机构:[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
Parkinson's disease (PD) is a common neurodegenerative disorder. To date, the diagnosis of PD relies mainly on clinical manifestations whereas neuropathological confirmation of the brain is only possible with postmortem studies. Neuronal loss in the substantia nigra pars compacta (SNc) associated with Lewy bodies/neurites is the pathological hallmark feature of PD. The major component of Lewy pathology (LP) is misfolded alpha-synuclein (alpha-SYN). There is evidence that the distribution of LP is not only limited to the brain but extends to peripheral tissues, including gastrointestinal tract, salivary glands, olfactory mucosa, skin, retina, adrenal gland, and heart. Sensitivity and specificity of alpha-SYN detection in PD vary greatly among studies due to methodological heterogeneity, such as sampling sites and size, tissue preparation, staining techniques, and antibodies used. Of note, alpha-SYN has also been found in preclinical and prodromal PD. Further in vivo studies focusing on favorable biopsy sites and standard techniques are needed to get better understanding of alpha-SYN deposits in preclinical, prodromal, and clinical PD.
基金:
Natural Science Foundation of ChinaNational Natural Science Foundation of China [81771367, 81571226, 2016YFC1306501]; Capital Characteristic Clinic Project [Z171100001017041]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z151100003915117, Z151100003915150]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7164254]
第一作者机构:[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
通讯作者:
通讯机构:[1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China[3]Parkinson’s Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[*1]Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, #119 South fourth Ring Road, West Road, 100070, Beijing, China.
推荐引用方式(GB/T 7714):
Ma Ling-Yan,Liu Gen-Liang,Wang Dong-Xu,et al.Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease[J].ACS CHEMICAL NEUROSCIENCE.2019,10(2):812-823.doi:10.1021/acschemneuro.8b00383.
APA:
Ma, Ling-Yan,Liu, Gen-Liang,Wang, Dong-Xu,Zhang, Mei-Mei,Kou, Wen-Yi&Feng, Tao.(2019).Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease.ACS CHEMICAL NEUROSCIENCE,10,(2)
MLA:
Ma, Ling-Yan,et al."Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease".ACS CHEMICAL NEUROSCIENCE 10..2(2019):812-823