机构：[1]Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, No.45 changchun St., Xicheng District, Beijing 100053, China老年医学科首都医科大学宣武医院[2]Parkinson’s disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China
Parkinson's disease (PD) is a very common neurodegenerative disorder characterized by the accumulation of alpha-synuclein (alpha-syn) into Lewy body (LB) inclusions and the loss of neuronmelanin (NM) containing dopamine (DA) neurons in the substantia nigra (SN). Pathological alpha-syn and NM are two prominent hallmarks in this selective and progressive neurodegenerative disease. Pathological alpha-syn can induce dopaminergic neuron death by various mechanisms, such as inducing oxidative stress and inhibiting protein degradation systems. Therefore, to explore the factors that trigger alpha-syn to convert from a non-toxic protein to toxic one is a pivotal question to clarify the mechanisms of PD pathogenesis. Many triggers for pathological alpha-syn aggregation have been identified, including missense mutations in the alpha-syn gene, higher concentration, and posttranslational modifications of alpha-Syn. Recently, the role of NM in inducing alpha-syn expression and aggregation has been suggested as a mechanism for this pigment to modulate neuronal vulnerability in PD. NM may be responsible for PD and age-associated increase and aggregation in alpha-syn. Here, we reviewed our previous study and other recent findings in the area of interaction between NM and alpha-syn.
基金：
the National Natural Science Foundation for financial support (No. 81171298).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
无
最新[2023]版：
大类|2 区生物学
小类|3 区生化与分子生物学
第一作者：
第一作者机构：[1]Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, No.45 changchun St., Xicheng District, Beijing 100053, China[2]Parkinson’s disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China
通讯作者：
通讯机构：[1]Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, No.45 changchun St., Xicheng District, Beijing 100053, China[2]Parkinson’s disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Shengli Xu,Piu Chan.Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease[J].BIOMOLECULES.2015,5(2):1122-42.doi:10.3390/biom5021122.
APA：
Shengli Xu&Piu Chan.(2015).Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.BIOMOLECULES,5,(2)
MLA：
Shengli Xu,et al."Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease".BIOMOLECULES 5..2(2015):1122-42
