机构：[1]Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, Beijing 100053, China老年医学科神经变性病教育部重点实验室首都医科大学宣武医院[2]Department of Pathology, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, Beijing 100053, China病理科首都医科大学宣武医院[3]Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo 156-8585, Japan[4]Department of General Surgery, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, Beijing 100053, China普通外科首都医科大学宣武医院[5]Forensic Medical Examination and Identification Center, Beijing Public Security Bureau, Beijing 100085, China
Although the increased prevalence of Parkinson's disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons contain significant amounts of neuromelanin, and the amount of neuromelanin increases with aging. In the present study, age-related changes in the number of nigral neurons expressing neuromelanin (NM), alpha-synuclein, and tyrosine hydroxylase (TH) were stereologically analyzed in the postmortem brains of 28 healthy humans with an age range of 17-84 years. Stereological counting of NM content, alpha-synuclein content, and TH immunoreactivity revealed significant accumulation of NM and alpha-synuclein in neurons during the aging process. In cells containing a large amount of NM, alpha-synuclein-immunoreactive cells in aged individuals outnumbered those of younger individuals. In non-NM cells, the alpha-synuclein expression profile was similar across age groups. Furthermore, TH-immunoreactive neurons decreased significantly with aging, which was associated with accumulation of NM and alpha-synuclein. Our results suggest that age related accumulation of NM might induce alpha-synuclein over-expression and thereby make dopamine neurons more vulnerable to injuries.
基金：
the Major State Basic Research Development Program of China (973 program) (No. 2006CB500701)
the National High Technology Research and Development Program of China (863 program) (No.2006AA02A408)
the National Natural Science Foundation of China (No. 30671950, 30430280)
第一作者机构：[1]Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, Beijing 100053, China[2]Department of Pathology, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurobiology and the Sino-Japan Joint Laboratory of Neurodegenerative diseases, Institute of Geriatrics of Beijing, Xuanwu Hospital of the Capital University of Medical Sciences, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Qi Xuan,Sheng-Li Xu,De-Hong Lu,et al.Increase expression of alpha-synuclein in aged human brain associated with neuromelanin accumulation[J].JOURNAL OF NEURAL TRANSMISSION.2011,118(11):1575-1583.doi:10.1007/s00702-011-0636-3.
APA：
Qi Xuan,Sheng-Li Xu,De-Hong Lu,Shun Yu,Ming Zhou...&Piu Chan.(2011).Increase expression of alpha-synuclein in aged human brain associated with neuromelanin accumulation.JOURNAL OF NEURAL TRANSMISSION,118,(11)
MLA：
Qi Xuan,et al."Increase expression of alpha-synuclein in aged human brain associated with neuromelanin accumulation".JOURNAL OF NEURAL TRANSMISSION 118..11(2011):1575-1583
