机构：[a]Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada[b]McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada[c]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[d]McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada[e]Department of Psychology, Neuropsychology Unit, McGill University, Montreal, QC, Canada
Executive dysfunction is frequently associated with episodic memory decline in amnestic mild cognitive impairment (aMCI) patients. Resting state executive control network (RS-ECN) represents a novel approach to interrogate the integrity of brain areas underlying executive dysfunction. The present study aims to investigate RS-ECN in aMCI and examine a possible link between changes in brain functional connectivity and declines in executive function. aMCI individuals (n = 13) and healthy subjects (n = 16) underwent cognitive assessment including executive function and high field functional magnetic resonance imaging. Individual RS-ECN maps were estimated using a seed-based cross-correlation method. Between groups RS-ECN functional connectivity comparison was assessed using voxel-wise statistic parametric mapping. aMCI individuals had reduced RS-ECN connectivity in the anterior cingulate cortex (ACC) and dorsal lateral prefrontal cortex (DLPFC), bilaterally. In contrast, aMCI showed increased connectivity in ventral lateral and anterior prefrontal cortex, bilaterally. Connectivity strength was associated with executive function in the ACC (r = 0.6213, p = 0.023) and right DLPFC (r = 0.6454, p = 0.017). Coexistence between connectivity declines and recruitment of brain regions outside the RS-ECN as reported here fits a brain reserve conceptual framework in which brain networks undergo remodeling in aMCI individuals.
基金：
Alzheimer’s Association (NIRG-08-92090 to PR),
Nussia & Andr′e Aisenstadt Foundation
Fonds de la recherche en sant′e duQu′ebec (16326 ),
National Nature Science Foundation of China (30700241),
the Beijing Scientific and Technological New Star Program (2007B069), Scholarship from Chinese Scholarship Council,
fellowship from Pfizer Canada,
Industry Canada/Montreal Neurological Institute Center of Excellence in Commercialization and Research grant
第一作者机构：[a]Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada[b]McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada[c]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
Liyong Wu,Ricardo Bernardi Soder,Doroth′ee Schoemaker,et al.Resting State Executive Control Network Adaptations in Amnestic Mild Cognitive Impairment[J].JOURNAL OF ALZHEIMERS DISEASE.2014,40(4):993-1004.doi:10.3233/JAD-131574.
APA：
Liyong Wu,Ricardo Bernardi Soder,Doroth′ee Schoemaker,Felix Carbonnell,Viviane Sziklas...&Pedro Rosa-Neto.(2014).Resting State Executive Control Network Adaptations in Amnestic Mild Cognitive Impairment.JOURNAL OF ALZHEIMERS DISEASE,40,(4)
MLA：
Liyong Wu,et al."Resting State Executive Control Network Adaptations in Amnestic Mild Cognitive Impairment".JOURNAL OF ALZHEIMERS DISEASE 40..4(2014):993-1004
