Advanced computed tomography (CT) technology has allowed for faster and more robust imaging. However, it has been a technical challenge to correctly synchronize CT acquisition with adequate and uniform arterial enhancement in the entire peripheral arterial tree. In this summary, we introduce a method of injection/acquisition optimization strategy based on a velocity-compensated CT angiography technique for the peripheral artery system, which is currently used in the United States. We believe that this imaging technique will provide additional information for our daily CT services in China.