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Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong

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机构： [a]Department of Neurology, Capital Medical University, Beijing, China [b]Cerebrovascular Diseases Research Institute, Xuanwu hospital of Capital Medical University, Beijing, China [c]Ministry of Education Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Beijing, China [d]Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA

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关键词： Intracerebral hemorrhage Hematoma Neurological function C-reactive protein Xueshuantong Injection

摘要：

Spontaneous intracerebral hemorrhage (ICH) leads to high mortality and morbidity. Currently, there is no effective therapy for ICH. Herein we conducted a clinical study in patients with acute ICH to investigate the efficacy of Xueshuantong Injection, a Chinese herbal prescription known for treatment of ischemic diseases in China. Patients (n = 63) were randomly assigned to control (n = 29) and Xueshuantong Injection treatment (175 mg/d, n = 34) groups. Both groups were evaluated using their history and vital signs. The National Institutes of Health Stroke Scale (NIHSS) scores, hematoma volume by CT scanning, and inflammatory factors were assessed before and after two weeks treatment. There were no significant differences in all parameters between two groups before treatment. The treatment group showed significant decreases in both NIHSS score and hematoma volume, compared to control group after treatment (P < 0.01 and P < 0.05, respectively). Furthermore, the inflammatory factors, as measured by leukocytes, neutrophil percentage and C-reactive protein values, were significantly reduced in treatment group compared to control group after treatment (P < 0.05, P < 0.05, P < 0.01 respectively). Our results showed that treatment with Xueshuantong Injection reduced inflammatory response and increased hematoma absorption, which significantly improved recovery of neurological function. This suggests Xueshuantong Injection as a potential treatment of patients with acute ICH. (C) 2012 Elsevier B.V. All rights reserved.

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出版当年[2011]版：

大类 | 3 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2010]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 3.2 最新五年平均 2.167 出版当年[2010版] 2.492 出版当年五年平均 2.324 出版前一年[2009版] 2.353 出版后一年[2011版]

第一作者：

第一作者机构： [a]Department of Neurology, Capital Medical University, Beijing, China [b]Cerebrovascular Diseases Research Institute, Xuanwu hospital of Capital Medical University, Beijing, China [c]Ministry of Education Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [d]Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM, USA [*1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.

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