机构：[a]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[b]Department of Neurology, Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Suzhou 215600, China[c]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China[d]Institutes of Neuroscience, Soochow University, Suzhou 215123, China
Background: Neutrophil to lymphocyte ratio (NLR) serves as a powerful inflammatory marker for predicting cardiovascular events. Here, we investigatewhether admission NLR is associatedwith hematoma volume, stroke severity, and 3-month outcomes in patients with acute intracerebral hemorrhage (ICH). Methods: 352 patients with acute ICH were prospectively identified in this study. Demographic characteristics, lifestyle risk factors, NIHSS score, hematoma volumes, and other clinical features were recorded for all participants. Patients was divided into quartiles based on the admission NLR levels (Q1: b2.78; Q2: 2.78-4.08; Q3: 4.08-7.85; Q4: >= 7.85). Multivariable linear regression models and logistic regression models were used to evaluate the association between NLR and hematoma volume, admission severity, or the outcomes after ICH. Results: Median NIHSS scores for each quartile (Q1 to Q4) were 6.0, 6.0, 6.0, and 11.0 (P=. 001), andmedian hematoma volumes were 9.5, 9.3, 9.1, and 15.0 ml (P =. 005), respectively. After adjusting the age, sex, and other potential risk factors, the patients in Q4 had higher NIHSS scores (P=. 042) and larger hematoma volume (P=.014). After 3-month follow-up, 148 poor outcomes (mRS, 3-6) and 47 all-cause deaths were documented. There were more patients with poor outcomes in Q4 than Q1. However, comparedwith the patients in Q1, those in Q4 were not associated with poor outcomes (P-trend= 0.379), and all-cause mortality (P-trend= 0.843) after adjust for other risk factors. Conclusions: Higher admissionNLR are associatedwith larger hematoma volume andmore serious stroke, but not 3-month outcomes in patients with acute ICH. (C) 2016 Elsevier Inc. All rights reserved.
基金：
Thisworkwas supported in part by grants fromthe National Natural
Science Foundation of China (81471195), Suzhou Clinical Research Center
of Neurological Disease (Szzx201503), the Second Affiliated Hospital
of Soochow University Preponderant Clinic Discipline Group Project
Funding (XKQ2015002). Thisworkwas also partly supported by the Priority
Academic Program Development of Jiangsu Higher Education Institutions
(PAPD).
第一作者机构：[a]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[b]Department of Neurology, Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Suzhou 215600, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, 215004, Suzhou, Jiangsu, China.[*2]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
推荐引用方式(GB/T 7714)：
Yaming Sun,Shoujiang You,Chongke Zhong,et al.Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients[J].AMERICAN JOURNAL OF EMERGENCY MEDICINE.2017,35(3):429-433.doi:10.1016/j.ajem.2016.11.037.
APA：
Yaming Sun,Shoujiang You,Chongke Zhong,Zhichao Huang,Lifang Hu...&Chun-Feng Liu.(2017).Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients.AMERICAN JOURNAL OF EMERGENCY MEDICINE,35,(3)
MLA：
Yaming Sun,et al."Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients".AMERICAN JOURNAL OF EMERGENCY MEDICINE 35..3(2017):429-433
