机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China[2]Department of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China[3]Department of Psychiatry, the Affiliated Guangji Hospital of Soochow University, Suzhou, China[4]Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China[5]Department of Neurology, the Affiliated Hospital of XuzhouMedical University, 99 West Huaihai road, Xuzhou, Jiangsu, China
Increasing evidences have demonstrated that inflammation is involved in the mechanisms of acute ischemic stroke (AIS). As an important and easy-to-measure inflammatory marker, neutrophil-to-lymphocyte ratio (NLR) shows a high association with mortality in patients with stroke in recent studies. In this study, we evaluated the prognostic role of NLR in patients with AIS. One hundred forty-three patients with AIS were enrolled. Clinical data were collected and the NLR was calculated from the admission blood work. The patients were followed up for 3 months after stroke onset. The occurrence of death and the major disability at 3 months after onset were end points in this study. Modified Rankin Scale score >= 3 was considered as poor outcome. In this study, 75 patients (52%) had poor outcome. We used binary logistic regression model to evaluate risk factor for poor outcome of AIS and found that the NLR was independently associated with the poor outcome of 3 months (P < 0.001). The optimal cutoff value for NLR as a predictor for 3-month outcome was 2.995. Therefore, in our study, high NLRs inversely predicted 3-month outcome in patients with AIS.
基金：
This work was supported by the grants from
National Natural Science Foundation of China (81361128010 and
81501081) and the Priority Academic Program Development of Jiangsu
Higher Education Institutions of China.
第一作者机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China[2]Department of Neurology, the Hefei Affiliated Hospital of Anhui Medical University, 246 Heping road, Hefei, Anhui, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu, China[4]Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China[5]Department of Neurology, the Affiliated Hospital of XuzhouMedical University, 99 West Huaihai road, Xuzhou, Jiangsu, China
推荐引用方式(GB/T 7714)：
Sen Qun,Yan Tang,Jing Sun,et al.Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke[J].NEUROTOXICITY RESEARCH.2017,31(3):444-452.doi:10.1007/s12640-017-9707-z.
APA：
Sen Qun,Yan Tang,Jing Sun,Zhaoxia Liu,Juncang Wu...&Wei Ge.(2017).Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke.NEUROTOXICITY RESEARCH,31,(3)
MLA：
Sen Qun,et al."Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke".NEUROTOXICITY RESEARCH 31..3(2017):444-452
