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Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis.

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China, [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China, [4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States, [5]Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States, [6]Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, United States, [7]Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing, China, [8]Department of Ultrasonography, Tiantan Hospital, Capital Medical University, Beijing, China, [9]School of Basic Medical Sciences, Capital Medical University, Beijing, China

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关键词： neutrophil-to-lymphocyte ratio stroke mortality functional outcome meta-analysis

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Background and purpose: Stroke is a leading cause of death and acquired disability in adults today. Inflammation plays an important role in the pathophysiology of stroke. The peripheral neutrophil-to-lymphocyte ratio (NLR) is an important global inflammatory indicator becoming more mainstream in stroke care. This meta-analysis aims to evaluate the relationship between the baseline NLR and acute ischemic and hemorrhagic stroke, as well as define the clinical significance of NLR in subtypes of ischemic stroke. Methods: This meta-analysis was registered in PROSPERO with the number CRD42018105305. We went through relevant articles from PubMed Central (PMC) and EMBASE. Prospective and retrospective studies were included if related to baseline NLR levels prior to treatment in patients with ischemic or hemorrhagic stroke. Studies were identified up until April 2019. The cutoff value for NLR and the sources of odds ratios (ORs)/risk ratios (RRs) were measured. Modified Rankin Scale (mRS) was used to investigate the outcomes during clinical follow-up. Predefined criteria were used to evaluate the risk of bias in eligible studies. P-values < 0.05 were considered statistically significant. STATA version 14.0 (STATA, College Station, TX) was used in all statistical analyses. Results: Thirty-seven studies with 43,979 individuals were included in the final analysis. Higher NLR levels were correlated with increased risk of ischemic stroke (ORs/RRs = 1.609; 95% CI = 1.283-2.019), unfavorable functional outcome at 3 months (ORs/RRs = 1.851; 95% CI = 1.325-2.584), and increased mortality in patients with ischemic stroke (ORs/RRs = 1.068; 95% CI = 1.027-1.111). While in terms of hemorrhagic stroke (including SAH and ICH), elevated NLR levels only had deleterious effects on mortality (ORs/RRs = 1.080; 95% CI = 1.018-1.146). Conclusions: Baseline NLR level is a promising predictor of the clinical outcomes in both ischemic and hemorrhagic stroke. In addition, elevated NLR is also associated with a high risk of ischemic stroke occurrence. However, future studies are needed to demonstrate the underlying mechanisms and further explain this association. Copyright © 2019 Song, Zhao, Rajah, Hua, Kang, Han, Ding and Meng.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

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出版当年[2017]版：

Q2 NEUROSCIENCES Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 3.508 出版当年[2017版] 4.297 出版当年五年平均 3.552 出版前一年[2016版] 2.635 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China, [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China,

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China, [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China,

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Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis.

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