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The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Ya Xin[1,2,3] * ; Shen Zhi Yuan[1,2,3] * ; Jia Yi Cun[1,2,3] ; Guo Xin[1,2,3] ; Guo Xiao Su[1,2,3] ; Xing Yuan[1,2,3,*2] ; Tian Shu Juan[1,2,3,*1] ;
机构： [1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. [2]Department of Neurology, Hebei Hospital, Xuanwu Hospital, Capital Medical University, Shijiazhuang, Hebei, People's Republic of China. [3]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, Hebei, People's Republic of China.
出处：
DOI： 10.2147/JIR.S418106
ISSN：

关键词： acute ischemic stroke short-term functional outcome neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio lymphocyte-to-monocyte ratio systemic inflammatory response index

摘要：
The aim of this study was to explore the relationship between functional prognosis and the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic inflammatory response index (SIRI) in patients with acute ischemic stroke (AIS) at discharge.A total of 861 patients with AIS were enrolled between January 2019 and December 2021. Blood cell counts were collected on admission. Logistic regression analysis was performed to assess the relationship between NLR, PLR, LMR, SIRI and adverse functional outcomes (modified Rankin scale score of 3-6) at discharge. We also used receiver operating characteristic (ROC) curves to estimate the overall ability of NLR, PLR, LMR and SIRI to judge short-term functional outcomes. Associations between NLR, PLR, LMR, and SIRI with length of hospital stay were analyzed by Spearman correlation test.A total of 194 patients (22.5%) had poor functional outcomes at discharge. Multivariate logistic regression analysis showed that NLR (odds ratio [OR], 1.060; 95% confidence interval [CI] 1.004-1.120, P=0.037), PLR (OR, 1.003; 95% CI 1.000-1.005, P=0.018), LMR (OR, 0.872; 95% CI 0.774-0.981, P=0.023) and SIRI (OR, 1.099; 95% CI 1.020-1.184, P=0.013) were independent factors for poor functional outcome. The odds ratios of the highest versus lowest quartiles of NLR, PLR and SIRI were 2.495 (95% CI 1.394-4.466), 1.959 (95% CI 1.138-3.373) and 1.866 (95% CI 1.106-3.146), respectively. The odds ratio of the lowest versus highest quartile of LMR was 2.300 (95% CI 1.331-3.975). The areas under the curve (AUCs) of the NLR, PLR, LMR, and SIRI to discriminate poor functional prognosis were 0.644, 0.587, 0.628, and 0.651, respectively. NLR, LMR, and SIRI were related with the length of hospital stay (P<0.05).NLR, PLR, LMR, and SIRI were associated with functional outcome at discharge in AIS patients. NLR, LMR and SIRI were related to hospitalization days in patients with AIS.© 2023 Zhang et al.

基金：
Hebei Natural Science Foundation (H2020206632) and National Key Research and Development Program of China (2022YFC3600503).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2021]版：
Q3 IMMUNOLOGY
最新[2023]版：
Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. [2]Department of Neurology, Hebei Hospital, Xuanwu Hospital, Capital Medical University, Shijiazhuang, Hebei, People's Republic of China. [3]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, Hebei, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. [2]Department of Neurology, Hebei Hospital, Xuanwu Hospital, Capital Medical University, Shijiazhuang, Hebei, People's Republic of China. [3]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, Hebei, People's Republic of China. [*1]Department of Neurology, The First hospital of Hebei Medical University, Shijiazhuang, Hebei, 050030, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Ya Xin,Shen Zhi Yuan,Jia Yi Cun,et al.The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke[J].JOURNAL OF INFLAMMATION RESEARCH.2023,16:3619-3630.doi:10.2147/JIR.S418106.
APA：
Zhang Ya Xin,Shen Zhi Yuan,Jia Yi Cun,Guo Xin,Guo Xiao Su...&Tian Shu Juan.(2023).The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke.JOURNAL OF INFLAMMATION RESEARCH,16,
MLA：
Zhang Ya Xin,et al."The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke".JOURNAL OF INFLAMMATION RESEARCH 16.(2023):3619-3630

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