机构：[a]Chinese Medicine Department,Xuanwu Hospital,Capital Medical University,45 Changchun Street,Beijing 100053,China首都医科大学宣武医院[b]Oncology Department,Oriental Hospital,Beijing University of Chinese Medicine,Beijing100078,China[c]Department of Pathobiology,College of Veterinary Medicine,Mississippi State University,240 Wise Center Drive,MS39762,USA
This study was designed to describe the relationship between methylglyoxal (MG) and the cognitive abilities of streptozotocin (STZ)-induced diabetic rats. Animal study revealed that the diabetic rats had significantly higher escape latency, a shorter average swimming time in the target quadrant and a longer average distance traveled to the platform in the Morris water maze compared with control group. The serum levels of MG in STZ rats were higher than in the control group and were positively correlated with the levels of serum glucose in the blood. In the STZ group, TUNEL-staining levels and the expression of cleaved Caspase-3 and Bax were significantly increased, whereas Bcl-2 expression was significantly decreased. Cell culture study showed that MG significantly increased the percentage of apoptotic hippocampal neurons. After the exposure to MG for 24 h, cleaved Caspase-3 and Bax expression increased, whereas Bcl-2 expression decreased. These data suggest a possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of MG, which may alter the expression levels of cleaved Caspase-3, Bcl-2 and Bax in the hippocampus. (C) 2012 Elsevier B.V. All rights reserved.
基金：
the National Natural Science Foundation of China(No.81041022)
the Beijing Municipal Natural Science Foundation(No.7102073)
the Beijing Nova Program(No.2008A090)
第一作者机构：[a]Chinese Medicine Department,Xuanwu Hospital,Capital Medical University,45 Changchun Street,Beijing 100053,China
共同第一作者：
通讯作者：
通讯机构：[a]Chinese Medicine Department,Xuanwu Hospital,Capital Medical University,45 Changchun Street,Beijing 100053,China
推荐引用方式(GB/T 7714)：
Xiaobo Huang,FenWang,WenqiangChen,et al.Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal[J].BRAIN RESEARCH.2012,1469:82-91.doi:10.1016/j.brainres.2012.06.011.
APA：
Xiaobo Huang,FenWang,WenqiangChen,YujingChen,NingqunWang&Kristine vonMaltzan.(2012).Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal.BRAIN RESEARCH,1469,
MLA：
Xiaobo Huang,et al."Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal".BRAIN RESEARCH 1469.(2012):82-91
