机构：[1]Department of Epidemiology and Health Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China[2]Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention, Xichang 615000, Sichuan province, China[3]Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital University of Medical Science, 45 Changchun Street, Xicheng district, Beijing 100053, China首都医科大学宣武医院[4]Department of Primary Health Care, University of Gothenburg, PO Box 454, SE 40530 Gothenburg, Sweden
The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with IT genotype. The association between the ADIPOQ +45 T>G polymorphism and the metabolic syndrome was independent of multiple confounders.
基金：
the National Natural Science Foundation of China(No 30671811)
第一作者机构：[1]Department of Epidemiology and Health Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
通讯作者：
通讯机构：[*1]Department of Epidemiology and Health Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
推荐引用方式(GB/T 7714)：
Xiaotong Li,Daying Wei,Huijing He,et al.Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China[J].ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION.2012,21(2):
APA：
Xiaotong Li,Daying Wei,Huijing He,Jianhua Zhang,Chunxiu Wang...&Guangliang Shan.(2012).Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China.ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION,21,(2)
MLA：
Xiaotong Li,et al."Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China".ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 21..2(2012)
