Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region
机构：[1]George Institute,University of Sydney, Sydney,Australia[2]Boden Institute, Sydney Medical School,University of Sydney, Sydney,Australia[3]Division of Epidemiology and Community Health,University of Minnesota, Minneapolis[4]University of Hong Kong, School of Public Health/Department of Community Medicine, Hong Kong[5]Department of Nutrition, Ambroise Pare′ Hospital and University of Versailles Saint Quentin en Yvelines, Boulogne-Billancourt, France[6]Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[7]Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia[8]Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia[9]Department of Health Science, Shiga University of Medical Science, Shiga,Japan[10]Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea[11]Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, West Bromwich, UK[12]Department of Epidemiology, Johns Hopkins University,Baltimore, MD
Background-Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results-Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and <1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C). Conclusion-Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted. (Circulation. 2011;124:2056-2064.)
基金：
National Health and Medical Research Council program grant （No. 571281）
the National R&D Program for Cancer Control, Ministry for Health,Welfare and Family Affairs, Republic of Korea (0920330)
第一作者机构：[1]George Institute,University of Sydney, Sydney,Australia[3]Division of Epidemiology and Community Health,University of Minnesota, Minneapolis[*1]Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Ste 300, Minneapolis, MN 55454.
通讯作者：
通讯机构：[*1]Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Ste 300, Minneapolis, MN 55454.
推荐引用方式(GB/T 7714)：
Rachel R. Huxley,Federica Barzi,Tai Hing Lam,et al.Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region[J].CIRCULATION.2011,124(19):2056-U82.doi:10.1161/CIRCULATIONAHA.111.028373.
APA：
Rachel R. Huxley,Federica Barzi,Tai Hing Lam,Sebastien Czernichow,Xianghua Fang...&Mark Woodward.(2011).Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region.CIRCULATION,124,(19)
MLA：
Rachel R. Huxley,et al."Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region".CIRCULATION 124..19(2011):2056-U82
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