机构：[1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China首都医科大学宣武医院[2]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics,Chinese Academy of Sciences, Beijing[3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology,Chinese Academy of Sciences, Beijing[4]State Key Laboratory of Membrane Biology, Institute of Zoology,Chinese Academy of Sciences, Beijing[5]Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing[6]University of Chinese Academy of Sciences, Beijing
Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.
基金：
This work was supported
by the Strategic Priority Research Program of the Chinese Academy
of Sciences (XDA16010100), the National Key Research and
Development Program of China (2015CB964800, 2017YFA0103304,
2017YFA0102802, 2014CB910503, and 2018YFA0107203), the
National Natural Science Foundation of China (grant No. 81625009,
81330008, 91749202, 91749123, 81371342, 81471414, 81422017,
31671429, 81601233, 81671377, 31601109, 31601158, 81771515,
81822018, 81870228, 81801399, 81801370, 31801010, and
81701388), the National High Technology Research and Development
Program of China (2015AA020307), CAS (KJZDEW-TZ-L05
and CXJJ-16M271), Program of Beijing Municipal Science and
Technology Commission (Z151100003915072), the Thousand Young
Talents Program of China, Advanced Innovation Center for Human
Brain Protection (117212), and Beijing Municipal Commission of
Health and Family Planning (PXM2018_026283_000002).
第一作者机构：[1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China[2]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics,Chinese Academy of Sciences, Beijing[5]Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing[6]University of Chinese Academy of Sciences, Beijing
共同第一作者：
通讯作者：
通讯机构：[1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China[3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology,Chinese Academy of Sciences, Beijing
推荐引用方式(GB/T 7714)：
Weiqi Zhang ,Moshi Song ,Jing Qu ,et al.Epigenetic Modifications in Cardiovascular Aging and Diseases[J].CIRCULATION RESEARCH.2018,123(7):773-786.doi:10.1161/CIRCRESAHA.118.312497.
APA：
Weiqi Zhang,,Moshi Song,,Jing Qu,&Guang-Hui Liu.(2018).Epigenetic Modifications in Cardiovascular Aging and Diseases.CIRCULATION RESEARCH,123,(7)
MLA：
Weiqi Zhang,,et al."Epigenetic Modifications in Cardiovascular Aging and Diseases".CIRCULATION RESEARCH 123..7(2018):773-786
医学