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Pathophysiology characterization of Alzheimer's disease in South China's aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)

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收录情况： ◇ SCIE

作者：
Liu Zhen[1] * ; Shi Dai[2] * ; Cai Yue[1] ; Li Anqi[1] ; Lan Guoyu[1] ; Sun Pan[1] ; Liu Lin[1] ; Zhu Yalin[1] ; Yang Jie[1] ; Zhou Yajing[1] ; Guo Lizhi[1] ; Zhang Laihong[1] ; Deng Shuqing[1] ; Chen Shuda[2] ; Yu Xianfeng[3] ; Chen Xuhui[1,4] ; Zhao Ruiyue[5] ; Wang Qingyong[6] ; Ran Pengcheng[7] ; Xu Linsen[8] ; Zhou Liemin[2] ; Sun Kun[9] ; Wang Xinlu[5] ; Peng Qiyu[1] ; Han Ying[1,3,10,11,12] ; Guo Tengfei[13,14] ;
机构： [1]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China. [2]Neurology Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, China. [3]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. [4]Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518000, China. [5]Department of Nuclear Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China. [6]Department of Neurology, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, 518107, China. [7]Department of Nuclear Medicine, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China. [8]Department of Medical Imaging, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, 518106, China. [9]Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, 518132, China. [10]School of Biomedical Engineering, Hainan University, Haikou, 570228, China. [11]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China. [12]National Clinical Research Center for Geriatric Diseases, Beijing, 100053, China. [13]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China. [14]Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
出处：
DOI： 10.1186/s13195-024-01458-z
ISSN：

关键词： Alzheimer’s disease Plasma biomarker PET MRI Chinese aging cohort

摘要：
The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge of Alzheimer's disease (AD). However, the characteristics and prevalence of AD in this area are still unclear due to the rarely available community-based neuroimaging AD cohort.Following the standard protocols of the Alzheimer's Disease Neuroimaging Initiative, the Greater-Bay-Area Healthy Aging Brain Study (GHABS) was initiated in 2021. GHABS participants completed clinical assessments, plasma biomarkers, genotyping, magnetic resonance imaging (MRI), β-amyloid (Aβ) positron emission tomography (PET) imaging, and tau PET imaging. The GHABS cohort focuses on pathophysiology characterization and early AD detection in the Guangdong-Hong Kong-Macao Greater Bay Area. In this study, we analyzed plasma Aβ42/Aβ40 (A), p-Tau181 (T), neurofilament light, and GFAP by Simoa in 470 Chinese older adults, and 301, 195, and 70 had MRI, Aβ PET, and tau PET, respectively. Plasma biomarkers, Aβ PET, tau PET, hippocampal volume, and temporal-metaROI cortical thickness were compared between normal control (NC), subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia groups, controlling for age, sex, and APOE-ε4. The prevalence of plasma A/T profiles and Aβ PET positivity were also determined in different diagnostic groups.The aims, study design, data collection, and potential applications of GHABS are summarized. SCD individuals had significantly higher plasma p-Tau181 and plasma GFAP than the NC individuals. MCI and dementia patients showed more abnormal changes in all the plasma and neuroimaging biomarkers than NC and SCD individuals. The frequencies of plasma A+/T+ (NC; 5.9%, SCD: 8.2%, MCI: 25.3%, dementia: 64.9%) and Aβ PET positivity (NC: 25.6%, SCD: 22.5%, MCI: 47.7%, dementia: 89.3%) were reported.The GHABS cohort may provide helpful guidance toward designing standard AD community cohorts in South China. This study, for the first time, reported the pathophysiology characterization of plasma biomarkers, Aβ PET, tau PET, hippocampal atrophy, and AD-signature cortical thinning, as well as the prevalence of Aβ PET positivity in the Guangdong-Hong Kong-Macao Greater Bay Area of China. These findings provide novel insights into understanding the characteristics of abnormal AD pathological changes in South China's older population.© 2024. The Author(s).

基金：
This study was funded by the Guangdong Basic and Applied Basic Science Foundation for Distinguished Young Scholars (Grant No. 2023B1515020113), the Shenzhen Science and Technology Program (Grant No. RCYX20221008092935096), the National Natural Science Foundation of China (Grant No. 82171197), and Shenzhen Bay Laboratory (Grant No. 21300061, Grant No. S211101002-2).
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
JCR分区：
出版当年[2022]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
共同第一作者：
通讯作者：
通讯机构： [13]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China. [14]Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
推荐引用方式(GB/T 7714)：
Liu Zhen,Shi Dai,Cai Yue,et al.Pathophysiology characterization of Alzheimer's disease in South China's aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)[J].ALZHEIMERS RESEARCH & THERAPY.2024,16(1):84.doi:10.1186/s13195-024-01458-z.
APA：
Liu Zhen,Shi Dai,Cai Yue,Li Anqi,Lan Guoyu...&Guo Tengfei.(2024).Pathophysiology characterization of Alzheimer's disease in South China's aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS).ALZHEIMERS RESEARCH & THERAPY,16,(1)
MLA：
Liu Zhen,et al."Pathophysiology characterization of Alzheimer's disease in South China's aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)".ALZHEIMERS RESEARCH & THERAPY 16..1(2024):84

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