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Association between postural tremor and risk of disability in community-dwelling older people

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机构: [1]Department of Neurology, Geriatrics, and Neurobiology, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Clinical Center for Parkinson's Disease, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Beijing, China [3]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China [4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
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关键词: Alzheimer’s disease biomarker plasma BDNF concentration

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The prevalence of postural tremor increases with age and the tremor has been found to be associated with aging-related physiological decline. However, whether postural tremor in older adults is associated with adverse outcomes such as disability is unclear. This study investigated the association between postural tremor and the risk of disability in activities of daily living (ADL) among community-dwelling older people.Data were derived from a population-based study of Chinese adults aged ≥55 years. Postural tremor was assessed at baseline using a two-step method (i.e., tremor screening followed by examination of positive cases). ADL disability was determined using an 8-item questionnaire, which covered the mobility and self-care domains of ADL. Participants free of ADL disability at baseline were followed for up to 4 years.The prospective analyses included 5868 participants. Participants with postural tremor were at greater risk of incident ADL disability, particularly disability in the mobility domain of ADL. After multivariate adjustment, postural tremor was not significantly associated with incident ADL disability (multivariate-adjusted relative risk [RR] = 1.05, 95% confidence interval [CI] = 0.77-1.43), and was marginally associated with incident disability in the mobility domain of ADL (multivariate-adjusted RR = 1.36, 95% CI = 0.98-1.88). The risk of mobility-related ADL disability was significantly increased among men, but not women, with postural tremor (multivariate-adjusted RR = 1.84, 95% CI = 1.11-3.05). Older age and an increased number of chronic comorbidities mainly explained the higher risk of ADL disability in older people with postural tremor.Postural tremor in older adults is associated with greater incidence of ADL disability, particularly mobility-related ADL disability. The association is largely due to older age and a higher prevalence of chronic comorbidities in older people with postural tremor. Postural tremor is not a strong independent predictor of ADL disability in older people.© 2022 The American Geriatrics Society.

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出版当年[2022]版:
大类 | 1 区 医学
小类 | 2 区 老年医学 2 区 老年医学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 老年医学 2 区 老年医学
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出版当年[2021]版:
Q1 GERIATRICS & GERONTOLOGY Q1 GERONTOLOGY
最新[2023]版:
Q1 GERIATRICS & GERONTOLOGY Q1 GERONTOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Department of Neurology, Geriatrics, and Neurobiology, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China
通讯作者:
通讯机构: [1]Department of Neurology, Geriatrics, and Neurobiology, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Clinical Center for Parkinson's Disease, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Beijing, China [3]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China [4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China [*1]Department of Neurobiology, Neurology, and Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.
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