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Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease.

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收录情况： ◇ SCIE

作者：
Jia Jianping[1,2,3,4] * ; Li Tingting[1] * ; Yang Jianwei[1] * ; Chen Baian[5] ; Qin Wei[1] ; Wei Cuibai[1] ; Song Yang[1] ; Wang Qigeng[1] ; Li Yan[1] ; Jia Longfei[1,2,3,4] ;
机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China [4]Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China [5]Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, School of Basic Medical Sciences, Capital Medical University, Beijing, China
出处：
DOI： 10.1186/s13195-022-00964-2
ISSN：

关键词： Alzheimer’s disease Amyloid-β Seeding activity Biomarker Blood

摘要：
To evaluate the diagnostic value of plasma β-amyloid (Aβ) seeding activity measured using a newly developed instrument to distinguish Alzheimer's disease (AD) from other forms of dementia.Seventy-nine AD patients, 64 non-AD dementia (NADD) patients, and 75 cognitively normal (NC) subjects were recruited in the study. To measure the levels of Aβ seeding activity in the plasma samples, we have developed an AD-seeds protein analyzer. We used receiver operating characteristic (ROC) curves to quantify the ability of plasma Aβ seeding activity to distinguish between AD and NADD or NC individuals. Spearman's correlation was used to examine the associations between plasma Aβ seeding activity and global cognitive function or conventional AD biomarkers.The Aβ seeding activities were 0.83 (0.58-1.16) A.U. in AD, 0.42 (0.04-0.74) A.U. in NADD and 0.42 (0.09-0.69) A.U. in NC, respectively. The Aβ seeding activity was able to identify AD patients and distinguish them from NC or NADD with high accuracy (AUC = 0.85-0.86). In addition, the plasma Aβ seeding activity showed a strong correlation with cognitive performance (mini-mental state examination, r = - 0.188; Montreal cognitive assessment, r = - 0.189; clinical dementia rating, r = 0.205) and conventional biomarkers (cerebrospinal fluid [CSF] Aβ42/40, r = -0.227; CSF T-tau/Aβ42, r = 0.239; CSF P-tau/Aβ42, r = 0.259).Our results confirmed that plasma Aβ seeding activity is an antibody-free and low-cost biomarker for the diagnosis of AD.Trial registration number NCT04850053.© 2022. The Author(s).

基金：
This study was supported by the National Key Scientifc Instrument and Equipment Development Project (31627803); the Key Project of the National Natural Science Foundation of China (81530036); the Key Project of the National Natural Science Foundation of China (U20A20354); Beijing Scholars Program; Beijing Brain Initiative from Beijing Municipal Science & Technology Commission (Z201100005520016, Z201100005520017).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
JCR分区：
出版当年[2020]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China [4]Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China [4]Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Jia Jianping,Li Tingting,Yang Jianwei,et al.Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease.[J].ALZHEIMERS RESEARCH & THERAPY.2022,14(1):21.doi:10.1186/s13195-022-00964-2.
APA：
Jia Jianping,Li Tingting,Yang Jianwei,Chen Baian,Qin Wei...&Jia Longfei.(2022).Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease..ALZHEIMERS RESEARCH & THERAPY,14,(1)
MLA：
Jia Jianping,et al."Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease.".ALZHEIMERS RESEARCH & THERAPY 14..1(2022):21

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