机构：[1]Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing, China.[2]Life Science Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi, China.[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.放射科首都医科大学宣武医院[4]Department of Radiology, Guang’anmen Hospital, Chinese Academy of Traditional medicine, Beijing, China.[5]Department of Radiology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China.[6]Departments of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Purpose: To investigate the acupoint specificity by exploring the effective connectivity patterns of the poststimulus resting brain networks modulated by acupuncture at the PC6, with the same meridian acupoint PC7 and different meridian acupoint GB37. Materials and Methods: The functional MRI (fMRI) study was performed in 36 healthy right-handed subjects receiving acupuncture at three acupoints, respectively. Due to the sustained effects of acupuncture, a novel experimental paradigm using the nonrepeated event-related (NRER) design was adopted. Psychophysical responses (deqi sensations) were also assessed. Finally, a newly multivariate Granger causality analysis (mGCA) was used to analyze effective connectivity patterns of the resting fMRI data taken following acupuncture at three acupoints. Results: Following acupuncture at PC6, the red nucleus and substantia nigra emerged as central hubs, in comparison with the fusiform gyrus following acupuncture at GB37. Red nucleus was also a target following acupuncture at PC7, but with fewer inputs than those of PC6. In addition, the most important target following acupuncture at PC7 was located at the parahippocampus. Conclusion: Our findings demonstrated that acupuncture at different acupoints may exert heterogeneous modulatory effects on the causal interactions of brain areas during the poststimulus resting state. These preliminary findings provided a clue to elucidate the relatively function-oriented specificity of acupuncture effects.
基金：
the Project for the National Key Basic Research and Development Program (973) under Grant No. 2011CB707700, the Chinese Academy of Sciences; Contract grant number: KGCX2-YW-129;
Contract grant sponsor: the National High Technology Research and Development Program of China (863 Program); Contract grant number: 2008AA01Z121; Contract grant number: 2007AA01Z338;
Contract grant sponsor: the National Natural Science Foundation of China; Contract grant number: 30873462; Contract grant number: 30970774; Contract grant number: 60901064; Contract grant number: 90924026; Contract grant number: 81071137; Contract grant number: 81071217.
第一作者机构：[1]Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[*]Institute of Automation, Chinese Academy of Science, P.O. Box 2728, Beijing, 100190, China.
推荐引用方式(GB/T 7714)：
Yuanyuan Feng,Lijun Bai,Wensheng Zhang,et al.Investigation of Acupoint Specificity by Multivariate Granger Causality Analysis From Functional MRI Data[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2011,34(1):31-42.doi:10.1002/jmri.22585.
APA：
Yuanyuan Feng,Lijun Bai,Wensheng Zhang,Ting Xue,Yanshuang Ren...&Jie Tian.(2011).Investigation of Acupoint Specificity by Multivariate Granger Causality Analysis From Functional MRI Data.JOURNAL OF MAGNETIC RESONANCE IMAGING,34,(1)
MLA：
Yuanyuan Feng,et al."Investigation of Acupoint Specificity by Multivariate Granger Causality Analysis From Functional MRI Data".JOURNAL OF MAGNETIC RESONANCE IMAGING 34..1(2011):31-42
