Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population
机构：[a]Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, No. 129 Mail Box, No. 10 Xitoutiao, Youanmenwai, Beijing 100069, PR China[b]Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan[c]Department of Cardiology, Xuanwu Hospital Capital Medical University, No. 45 Changchun Street, Xuanwu District, Beijing 100053, PR China心脏科（内科专业）首都医科大学宣武医院
Aims: The CIDEA gene is involved in energy metabolism and a non-synonymous single nucleotide polymorphism (SNP), V115F (G/T), is a risk factor for obesity in Swedish subjects and metabolic syndrome (MetS) in Japanese subjects. However, the risk allele was a G in Swedish subjects and a T in Japanese subjects. The present study investigated the association between this SNP and MetS in a Chinese population. Methods: Three hundred and fifty-one subjects evaluated at the Cardiac Clinic in Xuanwu Hospital for MetS risks were recruited. Anthropometric measurements, blood pressure, fasting bloodglucose, andbloodlipid levels were determined in addition to the polymorphism. Results: The proportion of subjects with MetS was significantly higher based on genotype, in the order: GG < GT < TT (p = 0.003). In multiple logistic regression analysis, the odds ratios for MetS in the GT and TT genotypes, compared to the referent GG genotype, were 2.26 (p = 0.003) and 2.89 (p = 0.002), respectively. Similar trends were observed for the related phenotypes of central obesity (GT: OR = 2.20, p = 0.004; TT: OR = 3.31, p = 0.002) and dyslipidemia (GT: OR = 1.73, p = 0.047; TT: OR = 2.10, p = 0.03). Conclusions: The T allele of the CIDEA V115F SNP is a risk factor for MetS and its related phenotypes in a Chinese population. # 2010 Elsevier Ireland Ltd. All rights reserved.
基金：
Natural Science Foundation of China (No.: 30800949); the Fund to Foster Excellent Talents of Beijing, China (No.: 20081D0501800211); the Natural Science Foundation of Beijing, China (No.: 7072032);
the Capital Medical University Basic and Clinic Medicine Collaboration Fund (No.: 09JL15); the Sino-Japan Friendship Medical Society, and the Newborn Star of Science Program(No.: 2009A47), Beijing,China.
第一作者机构：[a]Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, No. 129 Mail Box, No. 10 Xitoutiao, Youanmenwai, Beijing 100069, PR China
通讯作者：
通讯机构：[b]Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan[c]Department of Cardiology, Xuanwu Hospital Capital Medical University, No. 45 Changchun Street, Xuanwu District, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Ling Zhang,Ying Dai,Lili Bian,et al.Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population[J].DIABETES RESEARCH AND CLINICAL PRACTICE.2011,91(2):233-238.doi:10.1016/j.diabres.2010.10.016.
APA：
Ling Zhang,Ying Dai,Lili Bian,Wei Wang,Wei Wang...&Qi Hua.(2011).Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population.DIABETES RESEARCH AND CLINICAL PRACTICE,91,(2)
MLA：
Ling Zhang,et al."Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population".DIABETES RESEARCH AND CLINICAL PRACTICE 91..2(2011):233-238
