机构：[1]Division of Neurosurgery, Department of Surgery, University of British Columbia, and BC Children’s Hospital, Vancouver, British Columbia, Canada[2]Child and Family Research Institute, Vancouver, British Columbia, Canada[3]Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India[4]Department of Neurosurgery, Pennsylvania State Hershey Medical Center, Hershey, Pennsylvania[5]Division of Neurosurgery, Department of Surgery, The University of Hong Kong, and Queen Mary Hospital, Hong Kong[6]Department of Neurosurgery (SGH Campus), National Neuroscience Institute, Singapore[7]Division of Pediatric Neurosurgery, Children’s Memorial Hospital and Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois[8]Department of Neurosurgery (TTSH Campus), National Neuroscience Institute, Singapore[9]Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[10]Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong[11]Department of Neurosurgery, Hua Shan Hospital, Fudan University, Shanghai, China
BACKGROUND: Reported infection rates after ventriculoperitoneal shunt surgery vary from 1 to 25%. Antibiotic-impregnated (AI) catheters may reduce shunt infection rates, but this is uncertain. OBJECTIVE: To establish a prospective shunt registry to evaluate short-term (3-month) infection rates associated with ventriculoperitoneal shunts and standard or AI catheters during surgical treatment of hydrocephalus. METHODS: A prospective, multicenter, noncontrolled, open-label registry investigated patients with de novo catheter implantation or catheter replacement of an existing ventriculoperitoneal shunt. The primary outcome was shunt infection. RESULTS: A total of 440 patients were entered into the registry at 10 sites: 3 in North America, 2 in Singapore, 4 in China and 1 in India. Seven patients were excluded. Of the 433 remaining patients, 314 had new shunts and 119 were revisions. Shunt infections occurred in 14 of 433 patients (3.2%) overall and in 2 of 37 infants (5.2%) younger than 1 year. AI catheters were used in 46 of 433 patients at 7 centers. The shunt infection rate was 0 of 46 for shunts with AI catheters and 14 of 387 (3.6%) without AI catheters. Infection rates were similar with AI catheters, adjusting for age and catheter type. CONCLUSION: The overall shunt infection rate was lower than in previous multicentered studies. The low infection rate and low rate of AI catheter use precludes any meaningful statement regarding the value of AI catheters in reducing the infection rate. Consideration should be given to performing a well designed, adequately powered, prospective randomized controlled trial to determine whether AI catheters reduce shunt infection rates.
第一作者机构：[1]Division of Neurosurgery, Department of Surgery, University of British Columbia, and BC Children’s Hospital, Vancouver, British Columbia, Canada[*]Division of Pediatric Neurosurgery, BC Children’s Hospital, 4480 Oak St., Room K3-159, Vancouver, BC V6H 3V4, Canada.
通讯作者：
通讯机构：[*]Division of Pediatric Neurosurgery, BC Children’s Hospital, 4480 Oak St., Room K3-159, Vancouver, BC V6H 3V4, Canada.
推荐引用方式(GB/T 7714)：
Paul Steinbok,Ruth Milner,Deepak Agrawal,et al.A Multicenter Multinational Registry for Assessing Ventriculoperitoneal Shunt Infections for Hydrocephalus[J].NEUROSURGERY.2010,67(5):1303-1310.doi:10.1227/NEU.0b013e3181f07e76.
APA：
Paul Steinbok,Ruth Milner,Deepak Agrawal,Elana Farace,Gilberto K.K. Leung...&Liang Fu Zhou.(2010).A Multicenter Multinational Registry for Assessing Ventriculoperitoneal Shunt Infections for Hydrocephalus.NEUROSURGERY,67,(5)
MLA：
Paul Steinbok,et al."A Multicenter Multinational Registry for Assessing Ventriculoperitoneal Shunt Infections for Hydrocephalus".NEUROSURGERY 67..5(2010):1303-1310
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