Intra-arterial infusion of urokinase (UK) has been widely used However, the optimal infusion rate of the reagent has never been determined This was investigated in the acute stage of middle cerebral artery (MCA) embolism in the present study Sprague Dawley male rats (n=43) were randomly divided into sham-operation and five ischemic groups with urokinase administration at different infusion rates or without urokinase administration Ischemia was induced with MCA embolism Two hours after embolism, total urokinase (urokinase, 170,000U/kg) was given in groups A,B,C and D (n=8 each) at different rates 1,000 U (0 03 ml/min) per minute, 4,000U (0 12 ml/min), 10,000U (0 30 ml/min), and 16,000U (0 48 ml/min), respectively Group E received normal saline at a rate of 0 48 ml/min The sham-operation group (no embolism) received urokinase at (170,000U/kg, 1 5 ml, 16,000 U/min) During ischemia and thrombolysis, regional cerebral blood flow (CBF) was monitored by laser Doppler flowmetry The neurological deficits, Infarct volumes and mortalities in each group were determined The CBF in ischemic hemisphere were significantly (p<0 05) decreased after embolism in groups A similar to E at similar levels (27 32 +/- 8 20% to 34 71 +/- 6 84%) After different treatments, in group B 4,000U/min infusion of UK induced the best reperfusion, the least neurological deficits and infarct volume, as well as the least mortality and lowest Incidence of hemorrhage The effect of intra-artery thrombolysis of urokinase was related to the infusion rate Our study demonstrated an optimal infusion rate at 4,000U/min, suggesting relatively low levels of infusion are better able to improve brain reperfusion and reduce brain injury after stroke
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区核医学
JCR分区：
出版当年[2008]版：
Q4RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ4CLINICAL NEUROLOGY
最新[2023]版：
Q3CLINICAL NEUROLOGYQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ4CLINICAL NEUROLOGY
第一作者机构：[1]Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*]Department Cerebral Vascular Disease Institute, Neurosurgery Department Institution, Xuanwu Hospital Capital, Medical University Changchun, Street No. 45 Xuanwu District Beijing, 100053 China
推荐引用方式(GB/T 7714)：
X. GAN,Y. LUO,F. LING,et al.Outcome in Acute Stroke with Different Intra-Arterial Infusion Rate of Urokinase on Thrombolysis[J].INTERVENTIONAL NEURORADIOLOGY.2010,16(3):290-296.doi:10.1177/159101991001600311.
APA：
X. GAN,Y. LUO,F. LING,X. JI,J. CHEN&Y. DING.(2010).Outcome in Acute Stroke with Different Intra-Arterial Infusion Rate of Urokinase on Thrombolysis.INTERVENTIONAL NEURORADIOLOGY,16,(3)
MLA：
X. GAN,et al."Outcome in Acute Stroke with Different Intra-Arterial Infusion Rate of Urokinase on Thrombolysis".INTERVENTIONAL NEURORADIOLOGY 16..3(2010):290-296
