机构：[1]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统科技平台神经内科中美神经科学研究所[2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科[3]Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China[4]Nhwa Pharmaceutical Co. Ltd., Xuzhou, China[5]Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Salvinorin A (SA) exerts neuroprotection and improves neurological outcomes in ischemic stroke models in rodents. In this study, we investigated whether intranasal SA administration could improve neurological outcomes in a monkey ischemic stroke model. The stroke model was induced in adult male rhesus monkeys by occluding the middle cerebral artery M2 segment with an autologous blood clot. Eight adult rhesus monkeys were randomly administered SA or 10% dimethyl sulfoxide as control 20 min after ischemia. Magnetic resonance imaging was used to confirm the ischemia and extent of injury. Neurological function was evaluated using the Non-Human Primate Stroke Scale (NHPSS) over a 28-day observation period. SA significantly reduced infarct volume (3.9 ± 0.7 cm3 vs. 7.2 ± 1.0 cm3; P = 0.002), occupying effect (0.3 ± 0.2% vs. 1.4 ± 0.3%; P = 0.002), and diffusion limitation in the lesion (-28.2 ± 11.0% vs. -51.5 ± 7.1%; P = 0.012) when compared to the control group. SA significantly reduced the NHPSS scores to almost normal in a 28-day observation period as compared to the control group (P = 0.005). Intranasal SA reduces infarct volume and improves neurological outcomes in a rhesus monkey ischemic stroke model using autologous blood clot.
第一作者机构：[1]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.[2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China[*2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[5]Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
推荐引用方式(GB/T 7714)：
Longfei Wu,Di Wu,Jian Chen,et al.Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot.[J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.2021,41(4):723-730.doi:10.1177/0271678X20938137.
APA：
Longfei Wu,Di Wu,Jian Chen,Chunhua Chen,Tianqi Yao...&Xunming Ji.(2021).Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot..JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,41,(4)
MLA：
Longfei Wu,et al."Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot.".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 41..4(2021):723-730
医学