机构：[a]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China低氧适应转化医学北京市重点实验室[b]National Clinical Research Center for Geriatric Disorders, Beijing, China[c]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA[d]Department of Neurology, Luhe Hospital, Capital Medical University, Beijing, China[e]Department of Neurosurgery, Stanford University, CA, USA
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon has been termed hypoxic or ischemic preconditioning (HPC or IPC) and is well established in the heart and the brain. This review aims to discuss HPC and IPC with respect to their historical development and advancements in our understanding of the neurochemical basis for their neuroprotective role. Through decades of collaborative research and studies of HPC and IPC in other organ systems, our understanding of HPC and IPC-induced neuroprotection has expanded to include: early-(phosphorylation targets, transporter regulation, interfering RNA) and late- (regulation of genes like EPO, VEGF, and iNOS) phase changes, regulators of programmed cell death, members of metabolic pathways, receptor modulators, and many other novel targets. The rapid acceleration in our understanding of HPC and IPC will help facilitate transition into the clinical setting. (C) 2017 Published by Elsevier Ltd.
第一作者机构：[a]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China[b]National Clinical Research Center for Geriatric Disorders, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Xuan Wu Hospital, Capital Medical University[*1]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China[*1]Xuan Wu Hospital, Capital Medical University[*1]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Sijie Li,Adam Hafeez,Fatima Noorulla,et al.Preconditioning in neuroprotection: From hypoxia to ischemia[J].PROGRESS IN NEUROBIOLOGY.2017,157:79-91.doi:10.1016/j.pneurobio.2017.01.001.
APA：
Sijie Li,Adam Hafeez,Fatima Noorulla,Xiaokun Geng,Guo Shao...&Xunming Ji.(2017).Preconditioning in neuroprotection: From hypoxia to ischemia.PROGRESS IN NEUROBIOLOGY,157,
MLA：
Sijie Li,et al."Preconditioning in neuroprotection: From hypoxia to ischemia".PROGRESS IN NEUROBIOLOGY 157.(2017):79-91
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医学