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Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms

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机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China [3]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100050, China [4]Department of Gastroenterology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China

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关键词： Triclosan TCS Ischemic stroke Molecular docking Machine learning SHAP

摘要：

This study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between triclosan exposure and ischemic stroke (IS). A predictive model for TCS-associated IS risk was developed, complemented by mechanistic insights through the construction of miRNA-TF-mRNA regulatory networks and GeneMANIA functional prediction maps. SHAP analysis clarified feature contributions, confirming the model's robustness. Molecular docking analysis further validated the heightened genetic vulnerability to TCS exposure in IS pathogenesis. The research offers two key contributions: 1) A quantifiable framework for assessing environmental toxicant risks in cerebrovascular diseases, and 2) Strong evidence advocating for urgent innovation in biocompatible material and enhanced regulatory oversight of TCS use. These findings fill critical gaps in environmental neurotoxicology and establish new paradigms for predictive toxicological modeling. SYNOPSIS: Widespread triclosan exposure exacerbates human stroke risk, urging prioritized regulation of this persistent environmental toxicant in consumer and medical products.Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.

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出版当年[2025]版：

大类 | 2 区环境科学与生态学

小类 | 1 区毒理学 2 区环境科学

最新[2025]版：

大类 | 2 区环境科学与生态学

小类 | 1 区毒理学 2 区环境科学

第一作者：

第一作者机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China

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通讯作者：

通讯机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China

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