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Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses

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机构: [1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [2]China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China [3]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Beijing, China [4]Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA
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关键词: Cerebral ischemia Cytokine Immune cells Limb remote ischemic preconditioning

摘要:
Aims: Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to protect against ischemia-reperfusion injury after stroke. However, the mechanism underlying RIPC remains elusive. Methods: We generated a rat model of noninvasive RIPC by four repeated cycles of brief blood flow constriction (5 min) in the hindlimbs using a tourniquet. Blood was collected 1 h after preconditioning and 3 days after brain reperfusion. The impact of RIPC on immune cell and cytokine profiles prior to and after transient middle cerebral artery occlusion (MCAO) was assessed. Results: Remote ischemic preconditioning protects against focal ischemia and preserves neurological functions 3 days after stroke. Flow cytometry analysis demonstrated that RIPC ameliorates the post-MCAO reduction of CD3(+)CD8(+) T cells and abolishes the reduction of CD3(+)/CD161a(+) NKT cells in the blood. In addition, RIPC robustly elevates the percentage of B cells in peripheral blood, thereby reversing the reduction in the B-cell population after stroke. RIPC also markedly elevates the percentage of CD43(+)/CD172a(+) noninflammatory resident monocytes, without any impact on the percentage of CD43(-)/CD172a(+) inflammatory monocytes. Finally, RIPC induces IL-6 expression and enhances the elevation of TNF-alpha after stroke. Conclusion: Our results reveal dramatic immune changes during RIPC-afforded neuroprotection against cerebral ischemia.

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出版当年[2015]版:
大类 | 2 区 医学
小类 | 2 区 药学 3 区 神经科学
最新[2023]版:
大类 | 1 区 医学
小类 | 2 区 神经科学 2 区 药学
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出版当年[2014]版:
Q1 PHARMACOLOGY & PHARMACY Q2 NEUROSCIENCES
最新[2023]版:
Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [2]China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China [3]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Beijing, China
通讯作者:
通讯机构: [*1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [*2]China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.
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