Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection
机构：[a]Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China血液科首都医科大学宣武医院[b]Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
The major metabolic feature of diabetes is hyperglycemia which has been linked to the diabetes inflammatory processes, and diabetes-related vulnerability to infection. In the present study, we assessed how glucose affected PBMCs in type I interferon (IFN) production and subsequent signaling. We found that the moderately elevated glucose promoted, and high glucose suppressed type I IFN production, respectively. Pre-exposure to high glucose rendered monocytes more sensitive to IFN-alpha stimulation with heightened signaling, whereas, instantaneous addition of high glucose did not exhibit such effect. Consistent with this finding, the mRNA levels of IFN-alpha-induced IRF-7 in PBMCs were positively correlated with HbA1c levels of diabetes patients. Additionally, we found that high glucose promoted the production of other proinflammatory cytokines/chemokines. This study suggests that hyperglycemia may affect the inflammatory process in diabetes via promoting proinflammatory cytokines, as well as the host defense against microbial infections through impeding type I IFN production and signaling.
第一作者机构：[a]Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
通讯作者：
通讯机构：[*1]Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL 32610, USA.
推荐引用方式(GB/T 7714)：
Ronghua Hu,Chang-Qing Xia,Edward Butfiloski,et al.Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection[J].CLINICAL IMMUNOLOGY.2018,195:139-148.doi:10.1016/j.clim.2018.06.003.
APA：
Ronghua Hu,Chang-Qing Xia,Edward Butfiloski&Michael Clare-Salzler.(2018).Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection.CLINICAL IMMUNOLOGY,195,
MLA：
Ronghua Hu,et al."Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection".CLINICAL IMMUNOLOGY 195.(2018):139-148
