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Interferon regulatory factor-1 exerts inhibitory effect on neointimal formation after vascular injury

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机构： [1]Vascular Surgery, the Second Artillery General Hospital, Beijing 100088, China [2]Department of General Lab and Vascular Surgery, the First Affiated Hospital of Guangdong Medical College, Zhanjiang 524001, China [3]Vascular Institute, Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China

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关键词： Angiotensin Apoptosis Artery Inflammation Remodeling

摘要：

Objective: To investigate the effect of interferon regulatory factors (IRFs) on neointimal formation after vascular injury in the mouse, and its possible mechanism. Methods: Vascular injury was induced by polyethylene cuff placement around the left femoral artery of IRF-1-deficient mice and C57BL/6J mice. The mRNA expressions of IRF-1, IRF-2, angiotensin II type 2 (AT 2 ) receptor, interleukin-β converting enzyme (ICE), inducible nitric oxide synthase (iNOS) were detected by RT-PCR and immunohistochemical staining. Results: Neointimal formation after vascular injury was significantly greater in IRF-1-deficient mice than that in CS7BL/6J mice (P<0.05). In contrast, TUNEL-positive nuclei to total nuclei in the neointima and media in vascular smooth muscle cell (VSMC) in the injured artery significantly attenuated in IRF-1-deficient mice compared to C57BL/6J mice (P<0.05). The expressions of AT 2 receptor as well as pro-apoptotic genes such as ICE and iNOS in C57BL/6J mice were up-regulated in response to vascular injury, but this upregulation was attenuated in IRF-1-deficient mice. Conclusions: Our results suggest that IRF-1 induces VSMC apoptosis and inhibits neointimal formation after vascular injury at least partly due to the upregulation of AT 2 receptor, ICE and iNOS expressions. These results indicate that IRF-1 exerts an inhibitory effect on neointimal formation through the induction of apoptosis in VSMCs.

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第一作者：

第一作者机构： [1]Vascular Surgery, the Second Artillery General Hospital, Beijing 100088, China [2]Department of General Lab and Vascular Surgery, the First Affiated Hospital of Guangdong Medical College, Zhanjiang 524001, China

通讯作者：

通讯机构： [1]Vascular Surgery, the Second Artillery General Hospital, Beijing 100088, China [2]Department of General Lab and Vascular Surgery, the First Affiated Hospital of Guangdong Medical College, Zhanjiang 524001, China

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