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Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study

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机构： [1]Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. [2]Department of Non?communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China. [3]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Room 1504G, New Orleans, LA, USA. [4]Children’s Minnesota Research Institute, Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, USA. [5]Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China

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关键词： Inflammation C-reactive protein Insulin resistance Diabetes

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Background Inflammation and insulin resistance play crucial roles in the development of type 2 diabetes mellitus (T2DM). We aim to examine the temporal relationship between high-sensitivity C-reactive protein (hsCRP) and insulin resistance in non-diabetic adults and their joint effect on the development of hyperglycemia. Methods The longitudinal cohort from the Bogalusa Heart Study consisted of 509 non-diabetic adults (360 whites and 149 blacks, mean age = 42.8 years at follow-up) who had hsCRP, fasting glucose and insulin measured twice at baseline and follow-up over 6.8 years. Cross-lagged panel model was used to examine the temporal relationship between hsCRP and homeostasis model assessment for insulin resistance (HOMA-IR). Information on incident T2DM was collected in a survey in 6.1 years after the follow-up survey. Results After adjusting for race, sex, age, body mass index, smoking, alcohol drinking and follow-up years, the path coefficient from baseline hsCRP to follow-up HOMA-IR (beta(2) = 0.105, p = 0.009) was significant and greater than the path from baseline HOMA-IR to follow-up hsCRP (beta(1) = 0.005, p = 0.903), with p = 0.011 for the difference between beta(1) and beta(2). This one-directional path from baseline hsCRP to follow-up HOMA-IR was significant in the hyperglycemia group but not in the normoglycemia group. In addition, participants with high levels of baseline hsCRP and follow-up HOMA-IR had greater risks of T2DM (odds ratio, OR = 2.38, p = 0.035), pre-T2DM (OR = 2.27, p = 0.006) and hyperglycemia (OR = 2.18, p = 0.003) than those with low-low levels. Conclusions These findings suggest that elevated hsCRP is associated with future insulin resistance in non-diabetic adults, and their joint effect is predictive of the development of T2DM.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢 3 区心脏和心血管系统

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区心脏和心血管系统 1 区内分泌学与代谢

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出版当年[2017]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 8.5 最新[2023版] 8.9 最新五年平均 5.235 出版当年[2017版] 4.37 出版当年五年平均 4.752 出版前一年[2016版] 5.948 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. [2]Department of Non?communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China. [3]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Room 1504G, New Orleans, LA, USA.

通讯作者：

通讯机构： [3]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Room 1504G, New Orleans, LA, USA.

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Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study

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