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LncRNA CRNDE triggers inflammation through the TLR3-NF-B-Cytokine signaling pathway

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China; [2]CapitalBio Technol Co Ltd, Beijing, Peoples R China

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关键词： CRNDE toll-like receptor signaling pathway inflammation NF-B cytokine

摘要：

Colorectal neoplasia differentially expressed (CRNDE), an oncogene, is highly expressed in many tumor cells and affects cellular proliferation, migration, invasion, and apoptosis. Its function and mechanism of action is a research hotspot. In this study, microarray analysis was performed to discover the differentially expressed genes in CRNDE over-expression cells. RT2 Profiler PCR Array was used to study the expression of genes related to the toll-like receptor (TLR) pathway. We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll-like receptor signaling pathway, especially toll-like receptor-3-mediated MyD88-independent pathway. Furthermore, it up-regulated expression levels of downstream transcription factor such as nuclear factor kappa B and numerous cytokines. In contrast, CRNDE knockdown in glioma U87MG cell line showed an opposite trend in the expression of the above-mentioned genes. We speculated that CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll-like receptor pathway.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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无

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出版当年[2015]版：

Q2 ONCOLOGY

最新[2023]版：

无

影响因子： 0 最新[2023版] 0 最新五年平均 2.926 出版当年[2015版] 2.904 出版当年五年平均 3.611 出版前一年[2014版] 3.65 出版后一年[2016版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China;

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