机构：[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China首都医科大学宣武医院[2]Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People’s Republic of China[3]Department of Anatomy, Anhui Medical University, Hefei 230032, People’s Republic of China
E2 (oestradio1-17 beta) is an important hormone that regulates various cell functions including insulin production. hIPCs (human islet-derived precursor cells) are capable of proliferating and differentiating into cells that secrete insulin in response to glucose in vivo and in vitro. However, the effect of E2 on hIPCs is currently unclear. In this study, we found that ER alpha (oestrogen receptor alpha), but not ER beta, was expressed on hIPCs, and E2 promoted the proliferation and inhibited the differentiation of adult hIPCs. Although fetal hIPCs also express ER alpha, no effect of E2 on the fetal hIPCs was observed, suggesting differing roles of E2 at different stages of pancreatic development. This study indicates that E2 may be one of the key factors that control the turnover of adult pancreatic beta cells by regulating the proliferation and differentiation of adult hIPCs through ER alpha.
基金：
National High Technology Research and Development Program of China 863 Program (Grant no. 2006AA02A112 and Grant no. 2006AA02A116)
and Scientific Project of Beijing Municipal Science and Technology Commission (Grant no. D07050701350706).
第一作者机构：[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China[2]Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People’s Republic of China[3]Department of Anatomy, Anhui Medical University, Hefei 230032, People’s Republic of China
通讯作者：
通讯机构：[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China[2]Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhenhua Ren,Chunlin Zou,Huijun Ji,et al.Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha[J].CELL BIOLOGY INTERNATIONAL.2010,34(5):523-530.doi:10.1042/CBI20090390.
APA：
Zhenhua Ren,Chunlin Zou,Huijun Ji&Y. Alex Zhang.(2010).Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha.CELL BIOLOGY INTERNATIONAL,34,(5)
MLA：
Zhenhua Ren,et al."Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha".CELL BIOLOGY INTERNATIONAL 34..5(2010):523-530
