In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 mu M catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 mu M catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest.
基金：
National Natural Science FoundationNational Natural Science Foundation of China [81072765, 81173237]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7142053]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Chinese Med, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Chinese Med, Beijing, Peoples R China;[7]Capital Med Univ, Beijing Tiantan Hosp, Dept Chinese Med, 6 Tiantan Xili, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Yuan Chun-Xiao,Chu Takho,Liu Li,et al.Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2015,7(11):2474-2481.
APA：
Yuan, Chun-Xiao,Chu, Takho,Liu, Li,Li, Hao-Wen,Wang, Ya-Jie...&Fan, Yong-Ping.(2015).Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,7,(11)
MLA：
Yuan, Chun-Xiao,et al."Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 7..11(2015):2474-2481
