详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021China [2]Department of Neurosurgery, Xuanwu Hospital of Capital University of Medical Science, Beijing 10053, China [3]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA [4]Division of Cancer Genetics, Department of Advanced Medical Science, Nihon University School of Medicine, Tokyo 102-8251, Japan

出处：

DOI：

ISSN：

关键词： Celastrol apoptosis cell cycle proteasome glioma

摘要：

Glioma still remains a major health problem in the world. Celastrol has been proved to be an effective natural proteasome inhibitor and was used for treatment of autoimmune disease, chronic inflammation and neurodegenerative disease. However, its effect on glioma is unclear. In this study, we investigated the therapeutic effects of celastrol on C6 glioma cells. The results demonstrated that celastrol inhibited cell proliferation in a time-and dose-dependent manner, suppressed proteasome chymotrypsin-like activity and induced apoptosis and cell cycle arrest at G2/M phase in C6 cells. Proapoptosis proteins bax and caspase-3 were up-regulated, as well as cell cycle G2/M-related proteins cyclin B-1, p21 and p27. Conversely, anti-apoptosis proteins bcl-2 and XIAP and cell cycle regulator cyclin-dependent kinase 2 were down-regulated. Taken together, our data suggest that celastrol can suppress proteasome activity and induce apoptosis and cell cycle arrest in C6 glioma cells, which make it be a potential drug for glioma.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2009]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2008]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.7 最新[2023版] 2.2 最新五年平均 1.634 出版当年[2008版] 1.915 出版当年五年平均 1.634 出版前一年[2007版] 1.277 出版后一年[2009版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021China

通讯作者：

通讯机构： [1]Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo [2]Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction [3]Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest [4]Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma [5]Long noncoding RNA HOXD-AS2 regulates cell cycle to promote glioma progression [6]Unveiling the role of PSMA5 in glioma progression and prognosis [7]MACC1 silencing inhibits cell proliferation and induces cell apoptosis of lung adenocarcinoma cells through the beta-catenin pathway [8]O6-环己基甲基鸟嘌呤对垂体瘤细胞系MMQ细胞增殖、凋亡、周期的影响及其机制 [9]iASPP, a microRNA-124 target, is aberrantly expressed in astrocytoma and regulates malignant glioma cell migration and viability [10]钙卫蛋白与肿瘤关系研究进展