机构：[a]Laboratory of Neuroprotection, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA[b]Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA[c]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China放射科首都医科大学宣武医院
Understanding cerebrovascular responses to hyperoxia and hypercapnia is important for investigating exogenous regulation of cerebral hemodynamics. We characterized gas-induced vascular changes in the brains of anesthetized healthy rats using magnetic resonance imaging (MRI) while the rats inhaled 100% O-2 (hyperoxia) and 5% CO2 (hypercapnia). We used echo planar imaging (EPI), arterial spin labeling (ASL), and intravascular superparamagnetic iron oxide nanoparticles (SPION) to quantify vascular responses as measured by blood oxygenation level dependence (BOLD), cerebral blood flow (CBF), cerebral blood volume (CBV), microvascular volume (MVV), and vessel size index (VSI) in multiple brain regions. Hyperoxia resulted in a statistically significant increase in BOLD-weighted MRI signal and significant decrease in CBF and CBV (P < 0.05). During hypercapnia, we observed significant increases in BOLD signal, CBF, MVV, and CBV (P < 0.05). Despite the regional variability, general trends of vasoconstriction and vasodilation were reflected in VSI changes during O-2 and CO2 challenges. Interestingly, there was an evident spatial disparity between the O-2 and CO2 stimuli-induced functional activation maps; that is, cortical and subcortical regions of the brain exhibited notable differences in response to the two gases. Hemodynamic parameters measured in the cortical regions showed greater reactivity to CO2, whereas these same parameters measured in subcortical regions showed greater responsivity to O-2. Our results demonstrate significant changes of hemodynamic MRI parameters during systemic hypercapnia and hyperoxia in normal cerebral tissue. These gas-dependent changes are spatiotemporally distinctive, suggesting important feasibility for exogenously controlling local cerebral perfusion. (C) 2008 Elsevier Inc. All rights reserved.
基金：
grants from National Institute of Health (RO1-5R01EB002066).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类|2 区医学
小类|1 区神经成像1 区核医学2 区神经科学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2007]版：
Q1NEUROSCIENCESQ1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Laboratory of Neuroprotection, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA[b]Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA[c]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China
通讯作者：
通讯机构：[*]Harvard Medical School, Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Bldg. 149, 13th Street, Charlestown, MA 02129, USA
推荐引用方式(GB/T 7714)：
Jie Lu,Guangping Dai,Yasu Egi,et al.Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat[J].NEUROIMAGE.2009,45(4):1126-1134.doi:10.1016/j.neuroimage.2008.11.037.
APA：
Jie Lu,Guangping Dai,Yasu Egi,Shuning Huang,Seon Joo Kwon...&Young Ro Kim.(2009).Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat.NEUROIMAGE,45,(4)
MLA：
Jie Lu,et al."Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat".NEUROIMAGE 45..4(2009):1126-1134
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