机构：[1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China[2]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, People’s Republic of China放射科首都医科大学宣武医院
Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (lambda(1)) and transverse diffusivities (lambda(23)) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P = 0.001) and lambda(23) (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind. Ham Brain Mapp 30:220-227, 2009. (c) 2007 Wiley-Liss, Inc.
基金：
Contract grant sponsor: Natural Science Foundation of China,
Contract grant numbers: 30570509, 30425004, 60121302, 30670601;
Contract grant sponsor: National Key Basic Research and Development Program (973);
Contract grant number: 2003CB716100;
Contract grant sponsor: Beijing Scientific and Technological New Star Program;
Contract grant number: 2005B21
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2008]版：
大类|2 区医学
小类|1 区核医学2 区神经成像2 区神经科学
最新[2025]版：
大类|2 区医学
小类|2 区神经成像2 区核医学3 区神经科学
JCR分区：
出版当年[2007]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1NEUROSCIENCESQ1NEUROIMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROSCIENCES
第一作者机构：[1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China
通讯作者：
通讯机构：[1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China[2]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, People’s Republic of China
推荐引用方式(GB/T 7714)：
Ni Shu ,Jun Li ,Kuncheng Li ,et al.Abnormal Diffusion of Cerebral White Matter in Early Blindness[J].HUMAN BRAIN MAPPING.2009,30(1):220-227.doi:10.1002/hbm.20507.
APA：
Ni Shu,,Jun Li,,Kuncheng Li,,Chunshui Yu,&Tianzi Jiang.(2009).Abnormal Diffusion of Cerebral White Matter in Early Blindness.HUMAN BRAIN MAPPING,30,(1)
MLA：
Ni Shu,,et al."Abnormal Diffusion of Cerebral White Matter in Early Blindness".HUMAN BRAIN MAPPING 30..1(2009):220-227
