机构：[a]Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Xiannongtan Street, Xuanwu District, Beijing 100050, China[b]Institute of Cerebrovascular Diseases, Xuan Wu Hospital, Beijing 100053, China首都医科大学宣武医院[c]Center for Neurologic Diseases, Brigham & Women’s Hospital, Boston 02115, USA
L-3-n-Butylphthalide (L-NBP), as an anti-cerebral ischemia agent, has been shown to have therapeutic effects on learning and memory deficits induced by chronic cerebral hypoperfusion and A beta intracerebroventricular infusion in rats. In the present study, we investigated the neuroprotective effects of L-NBP on beta-amyloid (A beta)(25-35)-induced neuronal death/apoptosis and potential mechanisms in rat hippocampal neurons and human neuroblastoma SH-SY5Y cells. A beta(25-35) significantly reduced cell viability and increased the number of apoptotic-like cells, indicating that A beta(25-35)induced neurotoxicity. In addition, tau protein hyperphosphorylation was found to increase after A beta exposure. All of these phenotypes induced by A beta(25-35) were markedly reversed by L-NBP. Pretreatment With L-NBP prior to A beta(25-35) exposure significantly elevated cell viability, and reduced A beta(25-35)-induced nuclear fragmentation and early apoptosis. Furthermore, immunoreactivity for hyperphosphorylation tau protein was significantly decreased by L-NBP treatment. Our results suggest that L-NBP may protect neurons against A beta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
第一作者机构：[a]Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Xiannongtan Street, Xuanwu District, Beijing 100050, China[c]Center for Neurologic Diseases, Brigham & Women’s Hospital, Boston 02115, USA
通讯作者：
通讯机构：[a]Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Xiannongtan Street, Xuanwu District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Ying Peng,Changhong Xing,Cynthia A. Lemere,et al.L-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells[J].NEUROSCIENCE LETTERS.2008,434(2):224-229.doi:10.1016/j.neulet.2008.01.080.
APA：
Ying Peng,Changhong Xing,Cynthia A. Lemere,Guiquan Chen,Ling Wang...&Xiaoliang Wang.(2008).L-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells.NEUROSCIENCE LETTERS,434,(2)
