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Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice

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机构： [1]Beijing Research Laboratoryf or Brain Aging, Xuan-Wu Hospital,Capital Universityof Medical Sciences, Beijing100053,China [2]Karolinska Institutet, Neurotec, Section of Experimental Geriatrics,KFC,NovumPlan 4,14186 Huddinge, Sweden

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关键词： amyloid precursor protein diabetic encephalopathy electron microscopy immunohistochemistry microtubules tau protein

摘要：

The objective of this study was to investigate whether microtubular structure changes and tau protein hyperphosphorylation exist in hippocampal neurons of experimental diabetic mice, and to study the effect of amyloid precursor protein 17mer peptide. The results showed that the microtubules of hippocampal neurons of diabetic mice manifested prominent signs of fragmentation and dissolution, tau protein is hyperphosphorylated at Ser 199/Thr 202 sites, enzymes related to the phosphorylation and dephosphorylation of tau protein were diminished. The administration of amyloid precursor protein 17mer peptide could ameliorate the foregoing changes in diabetic mice. These results indicated that protein synthesis in the brain tissue of diabetic mice decreased. Amyloid precursor protein 17mer peptide acted as a neuroprotective agent that globally alleviates the disturbances due to impaired energy metabolism in diabetic mice.

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无

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2001]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q4 NEUROSCIENCES

影响因子： 1.6 最新[2023版] 1.6 最新五年平均 2.374 出版当年[2001版] 0 出版当年五年平均 2.696 出版前一年[2000版] 2.265 出版后一年[2002版]

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第一作者机构： [1]Beijing Research Laboratoryf or Brain Aging, Xuan-Wu Hospital,Capital Universityof Medical Sciences, Beijing100053,China

通讯作者：

通讯机构： [1]Beijing Research Laboratoryf or Brain Aging, Xuan-Wu Hospital,Capital Universityof Medical Sciences, Beijing100053,China

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