机构：[a]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China[b]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China[c]General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China[d]Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China放射科首都医科大学宣武医院
Temporal clustering analysis (TCA) has been proposed as a method to detect the brain responses of an fMRI time series when the time and location of the activation are completely unknown. But TCA is still incompetent in dealing with the time series of the whole brain due to the existence of many inactive pixels. If only active pixels are considered, the sensitivity of TCA will be improved greatly and it could be applied to the whole brain. In this study, some modifications were made to TCA to remove inactive pixels, and the applicability of the modified TCA to the whole brain was validated with a set of visual fMRI data. Based on the time series of the modified TCA, activations of the whole brain corresponding to the visual stimulation were detected. Compared with the previous TCA, the modified TCA method shows a significant improvement in the sensitivity to detect activation peaks of the whole brain. (c) 2007 Elsevier Inc. All rights reserved.
基金：
the National Natural Science Foundation of China (30570508).
第一作者机构：[a]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China[b]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
通讯作者：
通讯机构：[a]Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Na Lu,Bao-Ci Shan,Jian-Yang Xu,et al.An improved temporal clustering analysis method applied to whole-brain data in fMRI study[J].MAGNETIC RESONANCE IMAGING.2007,25(1):57-62.doi:10.1016/j.mri.2006.09.034.
APA：
Na Lu,Bao-Ci Shan,Jian-Yang Xu,Wei Wang&Kun-Cheng Li.(2007).An improved temporal clustering analysis method applied to whole-brain data in fMRI study.MAGNETIC RESONANCE IMAGING,25,(1)
MLA：
Na Lu,et al."An improved temporal clustering analysis method applied to whole-brain data in fMRI study".MAGNETIC RESONANCE IMAGING 25..1(2007):57-62
