机构：[a]School of Clinical Medicine, Southeast University, Nanjing 210009, China[b]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China[c]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China[d]Computational Neuroscience, University of Ulster, Magee Campus, Derry BT487JL, Northern Ireland, UK[e]Department of Neurology, XuanWu Hospital, The Capital University of Medical Sciences, Beijing 100053, China神经内科首都医科大学宣武医院
Amnestic mild cognitive impairment (aMCI) patients are thought to be particularly vulnerable to convert to clinical AD where functional disconnection is a major feature of the cortical neuropathology. However, the presence and extent of whole-brain connectivity disturbances is largely unknown in aMCI patients. Twenty-six aMCI patients and eighteen matched healthy subjects were evaluated at baseline and at mean 20 months follow up. Temporal correlations between spatially distinct regions were evaluated by using longitudinal resting-state fMRI. Compared to normal aging controls, patterns of abnormal interregional correlations in widely dispersed brain areas were identified in the patients, which also changed with disease progression. These disturbances were found particularly in subcortical regions and frontal cortex. Importantly, significantly decreased negative functional connection may be specifically associated with the development of aMCI patients. This suggests a compensatory mechanism is underway where local processing deficits are offset by recruitment of more dispersed cortical regions. In addition, the presence of this increased connectivity is seen to eventually weaken with disease progression. The results suggest that patterns of whole-brain functional connection may be a useful risk marker for conversion to AD in aMCI patients. (C) 2010 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of China (No. 30825014; No. 30971016), National Basic Research Program of China (973 Program) (No. 2007CB512308),
National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413),
National Key Technologies R&D Program During the 11th Five-year Plan Period-Intervention and
Control on Ageing Related Disease (Diagnosis and Treatment of Mild Cognitive Impairment) (No.2006BAI02B01)
and The Scientific Research of Foundation of Graduate of School of Southeast University (YBJJ0824).
第一作者机构：[a]School of Clinical Medicine, Southeast University, Nanjing 210009, China[b]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China
通讯作者：
通讯机构：[b]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China
推荐引用方式(GB/T 7714)：
Feng Bai,Wei Liao,David R. Watson,et al.Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients[J].BEHAVIOURAL BRAIN RESEARCH.2011,216(2):666-672.doi:10.1016/j.bbr.2010.09.010.
APA：
Feng Bai,Wei Liao,David R. Watson,Yongmei Shi,Yi Wang...&Zhijun Zhang.(2011).Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients.BEHAVIOURAL BRAIN RESEARCH,216,(2)
MLA：
Feng Bai,et al."Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients".BEHAVIOURAL BRAIN RESEARCH 216..2(2011):666-672
