机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Xin Jie Kou Wai Da Jie 19#, Beijing, China, 100088[b]Department of Radiology, Xuanwu Hospital, Capital Medical University, Changchun Street 45#, Xuanwu District, Beijing, China, 100053放射科首都医科大学宣武医院
Little is known about the difference of functional connectivity of semantic task between the recovery aphasic patients and normal subject. In this paper, an fMRI experiment was performed in a patient with aphasia following a left-sided ischemic lesion and normal subject. Picture naming was used as semantic activation task in this study. We compared the preliminary functional connectivity results of the recovery aphasic patient with the normal subject. The fMRI data were separated by independent component analysis (ICA) into 90 components. According to our experience and other papers, we chose a region of interest (ROI) of semantic (x=-57, y=-15, z=8, r=11 mm). From the 90 components, we chose one component as the functional connectivity of the semantic ROI according to one criterion. The criterion is the mean value of the voxels in the ROI. So the component of the highest mean value of the ROI is the functional connectivity of the ROL The voxel with its value higher than 2.4 was thought as activated (p < 0.05). And the functional connectivity networks of the normal subjects were t-tested as group network. From the result, we can know the semantic functional connectivity of stroke aphasic patient and normal subjects are different. The activated areas of the left inferior frontal gyrus and inferior/middle temporal gyrus are larger than the ones of normal. The activated area of the right inferior frontal gyrus is smaller than the ones of normal. The functional connectivity of stroke aphasic patient under semantic condition is different with the normal one. The focus of the stroke aphasic patient can affect the functional connectivity.
基金：
the Natural Science Key Foundation of Beijing (4061004),
the National Natural Science Foundation of China (60628101)
National High-tech R&D Program (863 Program, 2006AA01Z132).
语种：
外文
WOS：
第一作者：
第一作者机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Xin Jie Kou Wai Da Jie 19#, Beijing, China, 100088[b]Department of Radiology, Xuanwu Hospital, Capital Medical University, Changchun Street 45#, Xuanwu District, Beijing, China, 100053
通讯作者：
通讯机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Xin Jie Kou Wai Da Jie 19#, Beijing, China, 100088
推荐引用方式(GB/T 7714)：
Jie Lu,Xia Wu,Li Yao,et al.The functional connectivity of semantic task changes in the recovery from stroke aphasia[J].MEDICAL IMAGING 2007: PHYSIOLOGY, FUNCTION, AND STRUCTURE FROM MEDICAL IMAGES.2007,6511(PART 2):doi:10.1117/12.709034.
APA：
Jie Lu,Xia Wu,Li Yao,Kun-Cheng Li,Hua Shu&Qi Dong.(2007).The functional connectivity of semantic task changes in the recovery from stroke aphasia.MEDICAL IMAGING 2007: PHYSIOLOGY, FUNCTION, AND STRUCTURE FROM MEDICAL IMAGES,6511,(PART 2)
MLA：
Jie Lu,et al."The functional connectivity of semantic task changes in the recovery from stroke aphasia".MEDICAL IMAGING 2007: PHYSIOLOGY, FUNCTION, AND STRUCTURE FROM MEDICAL IMAGES 6511..PART 2(2007)
