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Cholera toxin B subunit labeling in lamina II of spinal cord dorsal horn following chronic inflammation in rats

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机构： [a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK [b]Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, PR China

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关键词： primary afferent cholera toxin B subunit inflammation dorsal horn hyperalgesia

摘要：

We have investigated the effect of inflammation on the labeling pattern of cholera toxin B subunit (CTB)-conjugated horseradish peroxidase, an A-fiber marker, by an intra-sciatic nerve injection of the tracer. Following chronic inflammation in one hind paw in rats, there was substantial CTB labeling in lamina 11 of the spinal dorsal horn, which is normally absent. However, there was no change in the labeling pattern of wheat germ agglutinin or fluoride resistant acid phosphatase/thiamine monophosphatase, two C-fiber markers. The CTB labeling in lamina II after peripheral nerve injury has been interpreted as central sprouting of A-fibers or uptake of the tracer by injured C-fibers. Our results suggest that chronic inflammation and nerve injury may share some common mechanisms in generating allodynia and hyperalgesia. (C) 2002 Published by Elsevier Science Ireland Ltd.

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无

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2000]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.5 最新[2023版] 2.5 最新五年平均 2.091 出版当年[2000版] 0 出版当年五年平均 2.085 出版前一年[1999版] 2.021 出版后一年[2001版]

第一作者：

第一作者机构： [a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK [*]Department of Pharmacology, Merck, Sharp & Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, UK

通讯作者：

通讯机构： [*]Department of Pharmacology, Merck, Sharp & Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, UK

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