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A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats

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机构: [a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK [b]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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关键词: primary efferent cholera toxin B subunit (CTB) Bandeiraea simplicifolia isolectin B4 (IB4) dorsal root ganglia (DRG)

摘要:
We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and then was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre AG-fibres which terminate in lamina I. (C) 2001 Elsevier Science B.V. All rights reserved.

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最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 神经科学
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出版当年[1999]版:
Q2 NEUROSCIENCES
最新[2023]版:
Q3 NEUROSCIENCES

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第一作者机构: [a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK [*]Present address: Department of Pharmacology, Merck, Sha1p and Dohme Research Laboratories Neuroscience Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.
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通讯机构: [*]Present address: Department of Pharmacology, Merck, Sha1p and Dohme Research Laboratories Neuroscience Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.
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