机构：[a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK[b]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[c]Department of Anaesthesia & Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown MA 02129, USA
We have investigated whether nerve injury or target deprivation is responsible for the injury induced central sprouting of A-fibres. Cholera toxin B subunit conjugated horseradish peroxidase was used to trace the termination of A-fibre primary afferents. Transection of the sciatic nerve induces central sprouting of sciatic myelinated A-fibre primary afferents into the spinal dorsal horn lamina II, which normally is the termination site of unmyelinated C-fibre primary afferents. The sprouting A-fibre terminals withdrew from lamina II after six to eight months. A second cut to the previously sectioned and ligated sciatic nerve re-triggered the central sprouting of A-fibre primary afferents into the spinal dorsal horn lamina II, suggesting that nerve injury per se rather than the deprivation of target tissues is the cause of central sprouting of A-fibre primary afferents. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
第一作者机构：[a]Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK[*]Department of Pharmacology, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.
通讯作者：
通讯机构：[*]Department of Pharmacology, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.
推荐引用方式(GB/T 7714)：
Qing-Ping Ma,Li Tian,Clifford J. Woolf.Resection of sciatic nerve re-triggers central sprouting of A-fibre primary afferents in the rat[J].NEUROSCIENCE LETTERS.2000,288(3):215-218.doi:10.1016/S0304-3940(00)01242-8.
APA：
Qing-Ping Ma,Li Tian&Clifford J. Woolf.(2000).Resection of sciatic nerve re-triggers central sprouting of A-fibre primary afferents in the rat.NEUROSCIENCE LETTERS,288,(3)
MLA：
Qing-Ping Ma,et al."Resection of sciatic nerve re-triggers central sprouting of A-fibre primary afferents in the rat".NEUROSCIENCE LETTERS 288..3(2000):215-218
