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Dual task interference in Parkinson's disease

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机构: [1]Associate Professor of Neurobiology, Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing [2]Chief, Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
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关键词: Attentional resource Automaticity Brain activity Central supervisor Dual task Functional magnetic resonance imaging (fMRI) Parkinson's disease

摘要:
Performing two tasks simultaneously (dual task performance) is a frequent activity in human life. Patients with Parkinson's disease (PD) commonly have more difficulty in performing dual tasks than healthy people. To date, research on the mechanisms of dual task interference in PD remains sparse. A recent study by Wu and Hallett in 2008 investigated the central neural correlates of dual task interference in PD, and demonstrated that dual task interference in PD is due to multiple reasons. First, the limitation of capacity of attentional resources is exceeded; second, PD patients perform tasks less automatically compared with normal subjects; and third, the central executive may be defective. However, our knowledge of this phenomenon is still far from complete and needs further investigation. © TOUCH BRIEFINGS 2009.

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第一作者机构: [1]Associate Professor of Neurobiology, Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing
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通讯机构: [*]Bldg 10, Rm 7D37, 10 Center Drive MSC 1428, Bethesda, Maryland 20892-1428.
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