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Preliminary studies on Alzheimer's disease using cDNA microarrays

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机构： [a]Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, PR China [b]State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, PR China [c]National Engineering and Research Center for Beijing Biochip, Jia 2# Qinghua West Road, Beijing 100084, PR China [d]Capital Biochip Corporation, Jia 2# Qinghua West Road, Beijing 100084, PR China [e]Xuanwu Hospital, 45# Changchun Street, Beijing 100053, PR China

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关键词： Alzheimer's disease C-terminal binding protein 1 cDNA microarray Transforming growth factor-β

摘要：

Alzheimer's disease (AD) is characterized by a progressive impairment of memory and intellectual functioning. The disease is a complex multi-factorial disease with the involvement of several possible genes. To study AD, a high-density cDNA array was developed to characterize the mRNA expression profile of 14 160 genes. The preliminary results support the amyloid cascade hypothesis as the mechanism of the disease. © 2002 Published by Elsevier Science Ireland Ltd.

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大类 | 2 区医学

小类 | 2 区老年医学 3 区细胞生物学

第一作者：

第一作者机构： [a]Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, PR China [c]National Engineering and Research Center for Beijing Biochip, Jia 2# Qinghua West Road, Beijing 100084, PR China

通讯作者：

通讯机构： [a]Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, PR China [b]State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, PR China [c]National Engineering and Research Center for Beijing Biochip, Jia 2# Qinghua West Road, Beijing 100084, PR China [d]Capital Biochip Corporation, Jia 2# Qinghua West Road, Beijing 100084, PR China

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