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Immediate remote ischemic postconditioning reduces cerebral damage in ischemic stroke mice by enhancing leptomeningeal collateral circulation

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收录情况： ◇ SCIE

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机构： [1]Department of Neurobiology, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan [5]Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida [6]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： animal models collateral circulation ischemic stroke monocytes/macrophages remote ischemic postconditioning

摘要：

Remote ischemic postconditioning (RIPC) is a promising neuroprotective strategy for ischemic stroke. Here, we employed a focal ischemic stroke mouse model to test the hypothesis that poststroke collateral circulation as a potent mechanism of action underlying the therapeutic effects of immediate RIPC. During reperfusion of cerebral ischemia, the mice were randomly assigned to receive RIPC, granulocyte colony-stimulating factor (G-CSF) as a positive control, or no treatment. At 24 hr, we found RIPC and G-CSF increased monocytes/macrophages in the dorsal brain surface and in the spleen, coupled with enhanced leptomeningeal collateral flow compared with nontreatment group. Blood monocytes depletion by 5-fluorouracil (5-FU) significantly limited the neuroprotection of RIPC or G-CSF treatment. The protein expression of proangiogenic factors such as Ang-2 was increased by ischemia, but treatment with either RIPC or G-CSF showed no further upregulation. Thus, immediate RIPC confers neuroprotection, in part, by enhancing leptomeningeal collateral circulation in a mouse model of ischemic stroke. © 2018 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生理学 3 区细胞生物学

JCR分区：

出版当年[2017]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

影响因子： 4.5 最新[2023版] 5.3 最新五年平均 3.923 出版当年[2017版] 3.83 出版当年五年平均 4.08 出版前一年[2016版] 4.522 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurobiology, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [6]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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Immediate remote ischemic postconditioning reduces cerebral damage in ischemic stroke mice by enhancing leptomeningeal collateral circulation

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