机构：[1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.[2]Department of Gynecologic Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.[3]Department of Radiation Oncology (Zhejiang Key Laboratory of Radiation Oncology), Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou 310022, China.
The clinical efficacy of definitive pelvic radiotherapy for primary tumors in patients with newly diagnosed organ metastatic cervical cancer is unclear. Therefore, we conducted a retrospective study to evaluate the efficacy of definitive pelvic radiotherapy combined with systemic chemotherapy in patients with organ metastatic cervical cancer.
We retrospectively analysed medical records from patients with newly diagnosed organ metastatic cervical cancer, all treated with chemotherapy at the Zhejiang Cancer Hospital between October 2006 and December 2016. Survival times were compared using the Kaplan-Meier method. The univariate log-rank method and multivariate Cox proportional hazard models were used to identify associated variables with survival.
A total of 48 patients were identified from 11,982 primary cervical cancer patients and divided into two groups according to treatment mode: 36 patients received chemotherapy combined with definitive pelvic radiotherapy (group A), 12 patients underwent chemotherapy with/without palliative pelvic radiotherapy (group B). Median follow-up was 14.4?months (range, 4.6-114.7?months). Median overall survival (OS) for group A and group B was 17.3 and 10?months, respectively. Using the univariate analysis, group A was found to have a better OS than group B (p?=?0.002). In multivariate analysis, group A (hazard ratio [HR], 0.32; 95% confidence interval [CI], 0.15-0.67, p?=?0.003) was associated with lower risk of death compared with group B. The main reason for treatment failure was found to be due to the progression of distant metastatic lesions in 36 patients (75%) from the whole cohort.
In this cohort of organ metastatic cervical cancer patients in good performance status, chemotherapy combined with definitive pelvic radiotherapy was associated with improved survival outcomes when compared with chemotherapy with/without palliative pelvic radiotherapy. Prospective trials evaluating definitive pelvic radiotherapy for newly diagnosed organ metastatic cervical cancer, therefore, are warranted.
基金：
The study was supported by a grant from the Zhejiang Medical Science and
Technology Foundation (No. 2018RC022).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区核医学4 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区核医学3 区肿瘤学
JCR分区：
出版当年[2017]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3ONCOLOGY
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ONCOLOGY
第一作者机构：[1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.[2]Department of Gynecologic Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
通讯作者：
通讯机构：[1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.[3]Department of Radiation Oncology (Zhejiang Key Laboratory of Radiation Oncology), Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou 310022, China.
推荐引用方式(GB/T 7714)：
Zhuomin Yin,Hanmei Lou,Huarong Tang,et al.Efficacy of radical doses of pelvic radiotherapy for primary tumor treatment in patients with newly diagnosed organ metastatic cervical cancer.[J].RADIATION ONCOLOGY.2019,14(1):82.doi:10.1186/s13014-019-1297-x.
APA：
Zhuomin Yin,Hanmei Lou,Huarong Tang,Juan Ni,Qiong Zhou&Ming Chen.(2019).Efficacy of radical doses of pelvic radiotherapy for primary tumor treatment in patients with newly diagnosed organ metastatic cervical cancer..RADIATION ONCOLOGY,14,(1)
MLA：
Zhuomin Yin,et al."Efficacy of radical doses of pelvic radiotherapy for primary tumor treatment in patients with newly diagnosed organ metastatic cervical cancer.".RADIATION ONCOLOGY 14..1(2019):82
