机构：[1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.首都医科大学?脑血管病研究所首都医科大学宣武医院[2]Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ischemic stroke is a leading cause of death and disability. Fear of intracranial hemorrhage (ICH) has been the primary reason for withholding tissue plasminogen activator (tPA) and thrombectomy, the only two widely accepted treatments for ischemic stroke. Thrombolysis treatment is only allowed in a very narrow time window (within 4.5-6 h). However, so far, other than the time window guideline, there is no reliable indicator available in the clinic to predict ICH before thrombolysis treatment. Recently, extensive research efforts have been devoted to the development of reliable indicators to predict ICH and safely guide the thrombolysis treatment. Accumulating evidence suggests that ischemic brain regions with a compromised blood-brain barrier (BBB) before tPA treatment develop ICH at the later time during thrombolytic reperfusion. Assessing BBB damage before thrombolysis could potentially help predict the risk of ICH after thrombolysis. This article reviews the literature reports on BBB damage biomarkers that have been developed in recent years, including biochemical markers such as BBB structural proteins, circulating brain microvascular endothelial cells, plasma albumin, and brain parenchyma proteins, as well as image markers such as magnetic resonance imaging assessment for BBB damage.
基金：
grants
from the National Natural Science Foundation of
China (81620108011, 81571175) and US National
Institutes of Health (P30GM103400).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
无
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区神经科学
第一作者：
第一作者机构：[1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China.
通讯作者：
通讯机构：[*1]Department of Pharmaceutical Sciences,University of New Mexico Health Sciences Center, NM 87131, USA.
推荐引用方式(GB/T 7714)：
Li Weili,Pan Rong,Qi Zhifeng,et al.Current progress in searching for clinically useful biomarkers of blood-brain barrier damage following cerebral ischemia.[J].Brain circulation.2018,4(4):145-152.doi:10.4103/bc.bc_11_18.
APA：
Li Weili,Pan Rong,Qi Zhifeng&Liu Ke Jian.(2018).Current progress in searching for clinically useful biomarkers of blood-brain barrier damage following cerebral ischemia..Brain circulation,4,(4)
MLA：
Li Weili,et al."Current progress in searching for clinically useful biomarkers of blood-brain barrier damage following cerebral ischemia.".Brain circulation 4..4(2018):145-152
